Seroatlas · Human Serome Atlas

ZNF620

Zinc finger protein 620

Also known as: MGC50836, ZN620_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZNG0
Gene
ZNF620
Ensembl
ENSG00000177842
Chromosome
3
Canonical length
422 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Centrosome

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q6ZNG0|ZNF620
     1  MFQTAWRQEP VTFEDVAVYF TQNEWASLDS VQRALYREVM LENYANVASL AFPFTTPVLV
    61  SQLEQGELPW GLDPWEPMGR EALRGICPGD EARTEKEGLT PKDHVSKETE SFRLMVGGLP
   121  GNVSQHLDFG SSLEQPQGHW IIKTKSKRRH FTDTSARHHE AYEVKNGEKF EKLGKNISVS
   181  TQLTTNQTNP SGQISYECGQ CGRYFIQMAD FHRHEKCHTG EKSFECKECG KYFRYNSLLI
   241  RHQIIHTGKK PFKCKECGKG LSSDTALIQH QRIHTGEKPY ECKECGKAFS SSSVFLQHQR
   301  FHTGEKLYEC NECWKTFSCS SSFTVHQRMH TGEKPYECKE CGKRLSSNTA LTQHQRIHTG
   361  EKPFECKECG KAFNQKITLI QHQRVHTGEK PYECKVCGKT FSWCGRFILH QKLHTQKTPV
   421  QA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF620 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
3.9 nTPM

Expression across tissuesHPA

Tissue

  • retina: 3.9 nTPM
  • thyroid gland: 3.2 nTPM
  • cerebellum: 3.1 nTPM
  • bone marrow: 3 nTPM
  • parathyroid gland: 2.5 nTPM
  • stomach: 2.5 nTPM

Single-cell type

  • erythrocyte progenitors: 33 nCPM
  • thyrotrophs: 18 nCPM
  • lactotrophs: 15 nCPM
  • endometrial glandular cells: 15 nCPM
  • gonadotrophs: 14 nCPM
  • retinal horizontal cells: 14 nCPM

Immune cell

  • basophil: 7.2 nTPM
  • T-reg: 3.5 nTPM
  • NK-cell: 2.9 nTPM
  • MAIT T-cell: 2.4 nTPM
  • naive CD8 T-cell: 2.2 nTPM
  • gdT-cell: 2.1 nTPM

Brain region

  • cerebellum: 11 nTPM
  • white matter: 8.8 nTPM
  • basal ganglia: 8.5 nTPM
  • thalamus: 7.5 nTPM
  • choroid plexus: 7.4 nTPM
  • midbrain: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
0.71
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF620 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF620 as an antibody target. Whether an autoantibody or antibody against ZNF620 could matter depends on whether native ZNF620 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF620 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF620 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF620. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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