Seroatlas · Human Serome Atlas

ZNF619

Zinc finger protein 619

Also known as: FLJ90764, ZN619_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N2I2
Gene: ZNF619
Ensembl: ENSG00000177873
Chromosome: 3
Canonical length: 560 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Intermediate filaments

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>Q8N2I2|ZNF619
     1  MGQPAPYAEG PIQGGDAGEL CKCDFLVSIS IPQTRSDIPA GARRSSMGPR SLDTCWGRGP
    61  ERHVHRLECN GVIFTHRNLC LPGGKTKTEN EEKTAQLNIS KESESHRLIV EGLLMDVPQH
   121  PDFKDRLEKS QLHDTGNKTK IGDCTDLTVQ DHESSTTERE EIARKLEESS VSTHLITKQG
   181  FAKEQVFYKC GECGSYYNPH SDFHLHQRVH TNEKPYTCKE CGKTFRYNSK LSRHQKIHTG
   241  EKPYSCEECG QAFSQNSHLL QHQKLHGGQR PYECTDCGKT FSYNSKLIRH QRIHTGEKPF
   301  KCKECGKAFS CSYDCIIHER IHNGEKPYEC KECGKSLSSN SVLIQHQRIH TGEKPYECKE
   361  CGKAFHRSSV FLQHQRFHTG EQLYKCNECW KTFSCSSRFI VHQRIHNGEK PYECQECGKT
   421  FSQKITLVQH QRVHTGEKPY ECKECGKAFR WNASFIQHQK WHTRKKLING TGLSAVKPYC
   481  PCAILSPLPP QHTCSALAPP GPPLSSSHAV VLPPSVPFFL LLPSSEKANP SPVQIAHFFQ
   541  DLAFPGKSSL QSPNPLSHSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF619 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 3.8 nTPM

Expression across tissuesHPA

Tissue

retina: 3.8 nTPM
bone marrow: 2.9 nTPM
parathyroid gland: 2.9 nTPM
spleen: 2.8 nTPM
thyroid gland: 2.8 nTPM
breast: 2.7 nTPM

Single-cell type

loop of henle epithelial cells: 3.2 nCPM
distal convoluted tubule cells: 3 nCPM
renal collecting duct intercalated cells: 2.6 nCPM
renal collecting duct principal cells: 2.3 nCPM
proximal tubule cells: 2.1 nCPM
renal connecting tubule cells: 2.1 nCPM

Immune cell

NK-cell: 1.3 nTPM
T-reg: 1.2 nTPM
eosinophil: 1.1 nTPM
myeloid DC: 1 nTPM
non-classical monocyte: 1 nTPM
intermediate monocyte: 0.9 nTPM

Brain region

white matter: 13 nTPM
basal ganglia: 11 nTPM
cerebral cortex: 10 nTPM
medulla oblongata: 9.8 nTPM
midbrain: 9.8 nTPM
thalamus: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF619 as an antibody target. Whether an autoantibody or antibody against ZNF619 could matter depends on whether native ZNF619 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF619 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF619 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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