Seroatlas · Human Serome Atlas

ZNF613

Zinc finger protein 613

Also known as: FLJ13590, ZN613_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PF04
Gene: ZNF613
Ensembl: ENSG00000176024
Chromosome: 19
Canonical length: 617 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

617 residues, UniProt reviewed canonical sequence.

>Q6PF04|ZNF613
     1  MIKSQESLTL EDVAVEFTWE EWQLLGPAQK DLYRDVMLEN YSNLVSVGYQ ASKPDALFKL
    61  EQGEPWTVEN EIHSQICPEI KKVDNHLQMH SQKQRCLKRV EQCHKHNAFG NIIHQRKSDF
   121  PLRQNHDTFD LHGKILKSNL SLVNQNKRYE IKNSVGVNGD GKSFLHAKHE QFHNEMNFPE
   181  GGNSVNTNSQ FIKHQRTQNI DKPHVCTECG KAFLKKSRLI YHQRVHTGEK PHGCSICGKA
   241  FSRKSGLTEH QRNHTGEKPY ECTECDKAFR WKSQLNAHQK IHTGEKSYIC SDCGKGFIKK
   301  SRLINHQRVH TGEKPHGCSL CGKAFSKRSR LTEHQRTHTG EKPYECTECD KAFRWKSQLN
   361  AHQKAHTGEK SYICRDCGKG FIQKGNLIVH QRIHTGEKPY ICNECGKGFI QKGNLLIHRR
   421  THTGEKPYVC NECGKGFSQK TCLISHQRFH TGKTPFVCTE CGKSCSHKSG LINHQRIHTG
   481  EKPYTCSDCG KAFRDKSCLN RHRRTHTGER PYGCSDCGKA FSHLSCLVYH KGMLHAREKC
   541  VGSVKLENPC SESHSLSHTR DLIQDKDSVN MVTLQMPSVA AQTSLTNSAF QAESKVAIVS
   601  QPVARSSVSA DSRICTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF613 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

prostate: 18 nTPM
breast: 6.6 nTPM
retina: 6.6 nTPM
placenta: 6.2 nTPM
parathyroid gland: 5.7 nTPM
thymus: 5.2 nTPM

Single-cell type

prostatic glandular cells: 26 nCPM
cytotrophoblasts: 9.3 nCPM
syncytiotrophoblasts: 8.8 nCPM
retinal pigment epithelial cells: 8.5 nCPM
platelets: 8.4 nCPM
distal convoluted tubule cells: 7.2 nCPM

Immune cell

eosinophil: 11 nTPM
naive CD8 T-cell: 10 nTPM
non-classical monocyte: 9.5 nTPM
naive B-cell: 9.2 nTPM
memory CD8 T-cell: 8.4 nTPM
naive CD4 T-cell: 7.7 nTPM

Brain region

hypothalamus: 11 nTPM
cerebellum: 9.8 nTPM
midbrain: 9.3 nTPM
medulla oblongata: 8.8 nTPM
white matter: 8.8 nTPM
pons: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF613 as an antibody target. Whether an autoantibody or antibody against ZNF613 could matter depends on whether native ZNF613 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF613 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF613 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...