Seroatlas · Human Serome Atlas

ZNF611

Zinc finger protein 611

Also known as: MGC5384, ZN611_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N823
Gene: ZNF611
Ensembl: ENSG00000213020
Chromosome: 19
Canonical length: 705 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

705 residues, UniProt reviewed canonical sequence.

>Q8N823|ZNF611
     1  MLREEAAQKR KGKEPGMALP QGRLTFRDVA IEFSLAEWKC LNPSQRALYR EVMLENYRNL
    61  EAVDISSKCM MKEVLSTGQG NTEVIHTGTL QRHESHHIGD FCFQEIEKEI HDIEFQCQED
   121  ERNGLEAPMT KIKKLTGSTD QHDHRHAGNK PIKDQLGSSF YSHLPELHIF QIKGEIGNQL
   181  EKSTNDAPSV STFQRISCRP QTQISNNYGN NPLNSSLLPQ KQEVHMREKS FQCNKSGKAF
   241  NCSSLLRKHQ IPHLGDKQYK CDVCGKLFNH EQYLACHDRC HTVEKPYKCK ECGKTFSQES
   301  SLTCHRRLHT GVKRYNCNEC GKIFGQNSAL LIDKAIDTGE NPYKCNECDK AFNQQSQLSH
   361  HRIHTGEKPY KCEECDKVFS RKSTIETHKR IHTGEKPYRC KVCDTAFTWH SQLARHRRIH
   421  TAKKTYKCNE CGKTFSHKSS LVCHHRLHGG EKSYKCKVCD KAFVWSSQLA KHTRIDCGEK
   481  PYKCNECGKT FGQNSDLLIH KSIHTGEQPY KCDECEKVFS RKSSLETHKI GHTGEKPYKC
   541  KVCDKAFACH SYLAKHTRIH SGEKPYKCNE CSKTFSHRSY LVCHHRVHSG EKPYKCNECS
   601  KTFSRRSSLH CHRRLHSGEK PYKCNECGNT FRHCSSLIYH RRLHTGEKSY KCTICDKAFV
   661  RNSLLSRHTR IHTAEKPYKC NECGKAFNQQ SHLSRHHRIH TGEKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF611 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 6.5 nTPM
seminal vesicle: 4.1 nTPM
thymus: 4.1 nTPM
pancreas: 4 nTPM
placenta: 4 nTPM
retina: 3.9 nTPM

Single-cell type

ocular epithelial cells: 181 nCPM
granulosa cells: 150 nCPM
endometrial glandular cells: 113 nCPM
proximal tubule cells: 111 nCPM
endometrial luminal cells: 109 nCPM
loop of henle epithelial cells: 95 nCPM

Immune cell

neutrophil: 9.7 nTPM
eosinophil: 8.9 nTPM
basophil: 7.3 nTPM
MAIT T-cell: 6.1 nTPM
gdT-cell: 5.4 nTPM
memory CD8 T-cell: 4.8 nTPM

Brain region

white matter: 15 nTPM
cerebellum: 13 nTPM
pons: 12 nTPM
basal ganglia: 12 nTPM
medulla oblongata: 11 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0.07
gnomAD missense Z: -1.51
DepMap mean gene effect: 0.29
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF611 as an antibody target. Whether an autoantibody or antibody against ZNF611 could matter depends on whether native ZNF611 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF611 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF611 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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