Seroatlas · Human Serome Atlas

ZNF610

Zinc finger protein 610

Also known as: FLJ36040, ZN610_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9Z0
Gene: ZNF610
Ensembl: ENSG00000167554
Chromosome: 19
Canonical length: 462 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>Q8N9Z0|ZNF610
     1  MLCDEEAQKR KAKESGMALP QGRLTFMDVA IEFSQEEWKS LDPGQRALYR DVMLENYRNL
    61  VFLGICLPDL SIISMLKQRR EPLILQSQVK IVKNTDGREC VRSVNTGRSC VLGSNAENKP
   121  IKNQLGLTLE AHLSELQLFQ AGRKIYRSNQ VEKFTNHRSS VSPLQKISSS FTTHIFNKYR
   181  NDLIDFPLLP QEEKAYIRGK SYEYECSEDG EVFRVRASLT NHQVIHTAEK PYKCTECGKV
   241  FSRNSHLVEH WRIHTGQKPY KCSECDKVFN RNSNLARHQR IHTGEKPHKC NECGKAFREC
   301  SGLTTHLVIH TGEKPYKCNE CGKNFRHKFS LTNHQRSHTA EKPYKCNECG KVFSLLSYLA
   361  RHQIIHSTEK PYKCNECGRA FHKRPGLMAH LLIHTGEKPY KCNECDKVFG RKLYLTNHQR
   421  IHTGERPYKC NACGKVFNQN PHLSRHRKIH AGENSLRTLQ ME

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF610 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
ovary: 7.8 nTPM
epididymis: 6.3 nTPM
retina: 5.8 nTPM
spinal cord: 5.4 nTPM
basal ganglia: 4.9 nTPM

Single-cell type

early spermatids: 44 nCPM
late primary spermatocytes: 26 nCPM
thyrotrophs: 17 nCPM
choroid plexus epithelial cells: 16 nCPM
retinal ganglion cells: 16 nCPM
bergmann glia: 14 nCPM

Immune cell

basophil: 1.7 nTPM
MAIT T-cell: 1.7 nTPM
naive CD4 T-cell: 1.7 nTPM
T-reg: 1.3 nTPM
NK-cell: 1.2 nTPM
gdT-cell: 1.1 nTPM

Brain region

midbrain: 13 nTPM
pons: 12 nTPM
hypothalamus: 12 nTPM
white matter: 11 nTPM
cerebellum: 11 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF610 as an antibody target. Whether an autoantibody or antibody against ZNF610 could matter depends on whether native ZNF610 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF610 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF610 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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