Seroatlas · Human Serome Atlas

ZNF606

Zinc finger protein 606

Also known as: FLJ14260, KIAA1852, ZN606_HUMAN, ZNF328

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXB4
Gene: ZNF606
Ensembl: ENSG00000166704
Chromosome: 19
Canonical length: 792 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) domain at its N-terminus, followed by contiguous C2H2 zinc finger motifs. The encoded protein is a nuclear protein that can act as a transcriptional repressor of growth factor-mediated signaling pathways in a reporter gene assay. This protein has been shown to interact with the SRY-box 9 gene product, and suppresses its transcriptional activity by inhibiting its DNA binding activity. Reduced expression of this gene promotes chondrocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

792 residues, UniProt reviewed canonical sequence.

>Q8WXB4|ZNF606
     1  MAAINPWASW GALTDQSWGM TAVDPWASWA LCPQYPAWHV EGSLEEGRRA TGLPAAQVQE
    61  PVTFKDVAVD FTQEEWGQLD LVQRTLYRDV MLETYGHLLS VGNQIAKPEV ISLLEQGEEP
   121  WSVEQACPQR TCPEWVRNLE SKALIPAQSI FEEEQSHGMK LERYIWDDPW FSRLEVLGCK
   181  DQLEMYHMNQ STAMRQMVFM QKQVLSQRSS EFCGLGAEFS QNLNFVPSQR VSQIEHFYKP
   241  DTHAQSWRCD SAIMYADKVT CENNDYDKTV YQSIQPIYPA RIQTGDNLFK CTDAVKSFNH
   301  IIHFGDHKGI HTGEKLYEYK ECHQIFNQSP SFNEHPRLHV GENQYNYKEY ENIFYFSSFM
   361  EHQKIGTVEK AYKYNEWEKV FGYDSFLTQH TSTYTAEKPY DYNECGTSFI WSSYLIQHKK
   421  THTGEKPYEC DKCGKVFRNR SALTKHERTH TGIKPYECNK CGKAFSWNSH LIVHKRIHTG
   481  EKPYVCNECG KSFNWNSHLI GHQRTHTGEK PFECTECGKS FSWSSHLIAH MRMHTGEKPF
   541  KCDECEKAFR DYSALSKHER THSGAKPYKC TECGKSFSWS SHLIAHQRTH TGEKPYNCQE
   601  CGKAFRERSA LTKHEIIHSG IKPYECNKCG KSCSQMAHLV RHQRTHTGEK PYECNKCGKS
   661  FSQSCHLVAH RRIHTGEKPY KCNQCERSFN CSSHLIAHRR THTGEKPYRC NECGKAFNES
   721  SSLIVHLRNH TGEKPYKCNH CEKAFCKNSS LIIHQRMHSG EKRFICSECG KAFSGHSALL
   781  QHQRNHSEEK LN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF606 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 11 nTPM
pituitary gland: 8.8 nTPM
ovary: 8.2 nTPM
spleen: 7.9 nTPM
fallopian tube: 7.8 nTPM
kidney: 7.6 nTPM

Single-cell type

cardiomyocytes: 398 nCPM
epicardial cells: 48 nCPM
adipocytes: 42 nCPM
choroid plexus epithelial cells: 38 nCPM
ependymal cells: 37 nCPM
adrenal medulla cells: 32 nCPM

Immune cell

basophil: 10 nTPM
naive B-cell: 7.3 nTPM
eosinophil: 6.3 nTPM
memory B-cell: 6.3 nTPM
plasmacytoid DC: 6.3 nTPM
naive CD4 T-cell: 6.2 nTPM

Brain region

choroid plexus: 28 nTPM
white matter: 28 nTPM
cerebellum: 26 nTPM
midbrain: 23 nTPM
basal ganglia: 23 nTPM
medulla oblongata: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.42
gnomAD missense Z: 1.19
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF606 as an antibody target. Whether an autoantibody or antibody against ZNF606 could matter depends on whether native ZNF606 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF606 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF606 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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