Seroatlas · Human Serome Atlas

ZNF605

Zinc finger protein 605

Also known as: ZN605_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86T29
Gene
ZNF605
Ensembl
ENSG00000196458
Chromosome
12
Canonical length
641 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

641 residues, UniProt reviewed canonical sequence.

>Q86T29|ZNF605
     1  MIQSQISFED VAVDFTLEEW QLLNPTQKNL YRDVMLENYS NLVFLEVWLD NPKMWLRDNQ
    61  DNLKSMERGH KYDVFGKIFN SSINIVHVGL RSHKCGTGEK SLKCPFDLLI PKNNCERKKI
   121  DELNKKLLFC IKPGRTHGGI KYCDCSTCRK SSNEEPWLTA NHITHTGVYL CMECGRFFNK
   181  KSQLVIHQRT HTGEKPYQCS ECGKAFSQKS LLTVHQRTHS GEKPHGCSEC QKAFSRKSLL
   241  ILHQRIHTGE KPYGCSECGK AFSRKSQLKR HQITHTIEKP YSCSECGKAF SQKLKLITHQ
   301  RAHTGEKPYP CSHCGKAFFW KSQLITHQRT HTGKKPYGCG ECQKAFSRNS LLIRHQRIHT
   361  GEKPYECNEC GEAFIRKPQL IKHQITHTGE KNYRCSDCEE AFFKKSELIR HQKIHLGEKP
   421  YGCIQCGKTF FGKSQLLTHH RTHTGEKPYE CSECGKAFTQ KSSLISHQRT HTGEKPYECS
   481  ECRKTFSEKS SLIHHQRTHT GEKPFECSEC RKAFAWKPQL LRHQRIHTGE KPYECSECGK
   541  AFVQKVQLIK HQRNHTGEKT YGCSDCAKAF FEKAQLIIHQ RIHTGERPYK CGECGKSFTR
   601  KSHLMRHQRI HTGDKYYGCN ECGTTFNRKS QLMIHQRNHI I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF605 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
9.5 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 9.5 nTPM
  • retina: 7.8 nTPM
  • thyroid gland: 6.5 nTPM
  • pituitary gland: 6.3 nTPM
  • parathyroid gland: 5.8 nTPM
  • epididymis: 5.1 nTPM

Single-cell type

  • tuft cells: 12 nCPM
  • megakaryocyte-erythroid progenitors: 4.3 nCPM
  • schwann cells: 4.2 nCPM
  • fallopian secretory cells: 4.1 nCPM
  • prostatic club cells: 4.1 nCPM
  • thymic myoid cells: 4.1 nCPM

Immune cell

  • memory B-cell: 0.5 nTPM
  • naive CD4 T-cell: 0.5 nTPM
  • basophil: 0.3 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • naive CD8 T-cell: 0.3 nTPM

Brain region

  • cerebellum: 15 nTPM
  • cerebral cortex: 13 nTPM
  • choroid plexus: 13 nTPM
  • white matter: 12 nTPM
  • amygdala: 11 nTPM
  • pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0.4
gnomAD missense Z
1.23
DepMap mean gene effect
0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF605 as an antibody target. Whether an autoantibody or antibody against ZNF605 could matter depends on whether native ZNF605 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF605 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF605 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF605. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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