Seroatlas · Human Serome Atlas

ZNF600

Zinc finger protein 600

Also known as: DKFZp686F06123, KR-ZNF1, ZN600_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNG1
Gene: ZNF600
Ensembl: ENSG00000189190
Chromosome: 19
Canonical length: 722 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

722 residues, UniProt reviewed canonical sequence.

>Q6ZNG1|ZNF600
     1  MMKEVLSTGQ GNTEVIHTGT LQRYQSYHIG DFCFQEIEKE IHDIEFQCQE DERNGHEAPM
    61  TKIKKLTGST DQHDHRHAGN KPIKDQLGSS FYSHLPELHI IQIKGKIGNQ FEKSTSDAPS
   121  VSTSQRISPR PQIHISNNYG NNSPNSSLLP QKQEVYMREK SFQCNESGKA FNCSSLLRKH
   181  QIPHLGDKQY KCDVCGKLFN HKQYLTCHCR CHTGEKPYKC NECGKSFSQV SSLTCHRRLH
   241  TAVKSHKCNE CGKIFGQNSA LVIHKAIHTG EKPYKCNECD KAFNQQSNLA RHRRIHTGEK
   301  PYKCEECDKV FSRKSTLESH KRIHTGEKPY KCKVCDTAFT WNSQLARHKR IHTGEKTYKC
   361  NECGKTFSHK SSLVCHHRLH GGEKSYKCKV CDKAFAWNSH LVRHTRIHSG GKPYKCNECG
   421  KTFGQNSDLL IHKSIHTGEQ PYKYEECEKV FSCGSTLETH KIIHTGEKPY KCKVCDKAFA
   481  CHSYLAKHTR IHSGEKPYKC NECSKTFRLR SYLASHRRVH SGEKPYKCNE CSKTFSQRSY
   541  LHCHRRLHSG EKPYKCNECG KTFSHKPSLV HHRRLHTGEK SYKCTVCDKA FVRNSYLARH
   601  TRIHTAEKPY KCNECGKAFN QQSQLSLHHR IHAGEKLYKC ETCDKVFSRK SHLKRHRRIH
   661  PGKKPYKCKV CDKTFGSDSH LKQHTGLHTG EKPYKCNECG KAFSKQSTLI HHQAVHGVGK
   721  LD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF600 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 8.3 nTPM

Expression across tissuesHPA

Tissue

small intestine: 8.3 nTPM
lymph node: 7.4 nTPM
spleen: 7.4 nTPM
tonsil: 7.4 nTPM
stomach: 7.1 nTPM
skin: 7 nTPM

Single-cell type

nk-cells: 59 nCPM
endometrial luminal cells: 54 nCPM
syncytiotrophoblasts: 53 nCPM
ocular epithelial cells: 48 nCPM
endometrial glandular cells: 47 nCPM
urothelial cells: 46 nCPM

Immune cell

NK-cell: 53 nTPM
gdT-cell: 22 nTPM
MAIT T-cell: 13 nTPM
naive CD8 T-cell: 12 nTPM
memory CD8 T-cell: 11 nTPM
memory B-cell: 7.8 nTPM

Brain region

cerebellum: 20 nTPM
pons: 4.1 nTPM
choroid plexus: 3.6 nTPM
thalamus: 3.2 nTPM
white matter: 3.2 nTPM
medulla oblongata: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.73
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF600 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF600 as an antibody target. Whether an autoantibody or antibody against ZNF600 could matter depends on whether native ZNF600 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF600 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF600 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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