Seroatlas · Human Serome Atlas

ZNF599

Zinc finger protein 599

Also known as: FLJ30663, ZN599_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96NL3
Gene
ZNF599
Ensembl
ENSG00000153896
Chromosome
19
Canonical length
588 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

588 residues, UniProt reviewed canonical sequence.

>Q96NL3|ZNF599
     1  MAAPALALVS FEDVVVTFTG EEWGHLDLAQ RTLYQEVMLE TCRLLVSLGH PVPKPELIYL
    61  LEHGQELWTV KRGLSQSTCA GEKAKPKITE PTASQLAFSE ESSFQELLAQ RSSRDSRLGQ
   121  ARDEEKLIKI QEGNLRPGTN PHKEICPEKL SYKHDDLEPD DSLGLRVLQE RVTPQDALHE
   181  CDSQGPGKDP MTDARNNPYT CTECGKGFSK KWALVRHQQI HAGVKPYECN ECGKACRYMA
   241  DVIRHMRLHT GEKPYKCIEC GKAFKRRFHL TEHQRIHTGD KPYECKECGK AFTHRSSFIQ
   301  HNMTHTREKP FLCKECGKAF YYSSSFAQHM RIHTGKKLYE CGECGKAFTH RSTFIQHNVT
   361  HTGEKPFLCK ECGKTFCLNS SFTQHMRIHT GEKPYECGEC GKAFTHRSTF IRHKRTHTGE
   421  KPFECKECGK AFCDSSSLIQ HMRIHTGEKP YECSECGKAF THHSVFIRHN RTHSGQKPLE
   481  CKECAKAFYY SSSFTRHMRI HTGEKPYVCR ECGKAFTQPA NFVRHNRIHT GEKPFECKEC
   541  EKAFCDNFAL TQHMRTHTGE KPFECNECGK TFSHSSSFTH HRKIHTRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF599 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • testis: 13 nTPM
  • epididymis: 11 nTPM
  • choroid plexus: 11 nTPM
  • pituitary gland: 10 nTPM
  • thyroid gland: 10 nTPM
  • kidney: 10 nTPM

Single-cell type

  • early spermatids: 84 nCPM
  • late primary spermatocytes: 60 nCPM
  • late spermatids: 45 nCPM
  • epididymal efferent duct ciliated cells: 34 nCPM
  • epididymal principal cells: 34 nCPM
  • fallopian tube ciliated cells: 33 nCPM

Immune cell

  • eosinophil: 3.5 nTPM
  • memory CD4 T-cell: 3.5 nTPM
  • naive CD4 T-cell: 3.5 nTPM
  • NK-cell: 3.5 nTPM
  • gdT-cell: 3.4 nTPM
  • naive CD8 T-cell: 3.2 nTPM

Brain region

  • choroid plexus: 12 nTPM
  • white matter: 9.7 nTPM
  • midbrain: 8.9 nTPM
  • basal ganglia: 8.8 nTPM
  • cerebellum: 8.6 nTPM
  • hypothalamus: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
-0.13
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF599 as an antibody target. Whether an autoantibody or antibody against ZNF599 could matter depends on whether native ZNF599 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF599 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF599 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF599. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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