Seroatlas · Human Serome Atlas

ZNF597

Zinc finger protein 597

Also known as: FLJ33071, HIT-4, ZN597_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LX8
Gene: ZNF597
Ensembl: ENSG00000167981
Chromosome: 16
Canonical length: 424 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a protein with multiple zinc finger domains. Loss of the related gene in rodents results in defects in neural development and embryonic lethality in mutant homozygotes. This gene is adjacent to a differentially methylated region (DMR) and is imprinted and maternally expressed. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>Q96LX8|ZNF597
     1  MASMPPTPEA QGPILFEDLA VYFSQEECVT LHPAQRSLSK DGTKESLEDA ALMGEEGKPE
    61  INQQLSLESM ELDELALEKY PIAAPLVPYP EKSSEDGVGN PEAKILSGTP TYKRRVISLL
   121  VTIENHTPLV ELSEYLGTNT LSEILDSPWE GAKNVYKCPE CDQNFSDHSY LVLHQKIHSG
   181  EKKHKCGDCG KIFNHRANLR THRRIHTGEK PYKCAKCSAS FRQHSHLSRH MNSHVKEKPY
   241  TCSICGRGFM WLPGLAQHQK SHSAENTYES TNCDKHFNEK PNLALPEETF VSGPQYQHTK
   301  CMKSFRQSLY PALSEKSHDE DSERCSDDGD NFFSFSKFKP LQCPDCDMTF PCFSELISHQ
   361  NIHTEERPHK CKTCEESFAL DSELACHQKS HMLAEPFKCT VCGKTFKSNL HLITHKRTHI
   421  KNTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF597 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

testis: 3.6 nTPM
lung: 2.2 nTPM
retina: 2.2 nTPM
cerebral cortex: 2.1 nTPM
placenta: 2.1 nTPM
lymph node: 2 nTPM

Single-cell type

alveolar cells type 1: 13 nCPM
late primary spermatocytes: 12 nCPM
tuft cells: 12 nCPM
gastric progenitor cells: 9 nCPM
undifferentiated spermatogonia: 9 nCPM
differentiating spermatogonia: 8.7 nCPM

Immune cell

eosinophil: 8.8 nTPM
basophil: 3.1 nTPM
intermediate monocyte: 1.6 nTPM
MAIT T-cell: 1.5 nTPM
naive CD4 T-cell: 1.2 nTPM
T-reg: 1.2 nTPM

Brain region

hypothalamus: 4.7 nTPM
cerebral cortex: 4.3 nTPM
white matter: 3.9 nTPM
basal ganglia: 3.8 nTPM
midbrain: 3.8 nTPM
thalamus: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.07
gnomAD missense Z: -0.54
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF597 as an antibody target. Whether an autoantibody or antibody against ZNF597 could matter depends on whether native ZNF597 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF597 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF597 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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