Seroatlas · Human Serome Atlas

ZNF596

Zinc finger protein 596

Also known as: ZN596_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TC21
Gene
ZNF596
Ensembl
ENSG00000172748
Chromosome
8
Canonical length
504 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoli,Mitochondria

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>Q8TC21|ZNF596
     1  MPSPDSMTFE DIIVDFTQEE WALLDTSQRK LFQDVMLENI SHLVSIGKQL CKSVVLSQLE
    61  QVEKLSTQRI SLLQGREVGI KHQEIPFIQH IYQKGTSTIS TMRSHTQEDP FLCNDLGEDF
   121  TQHIALTQNV ITYMRTKHFV SKKFGKIFSD WLSFNQHKEI HTKCKSYGSH LFDYAFIQNS
   181  ALRPHSVTHT REITLECRVC GKTFSKNSNL RRHEMIHTGE KPHGCHLCGK AFTHCSDLRK
   241  HERTHTGEKP YGCHLCGKAF SKSSNLRRHE MIHTREKAQI CHLCGKAFTH CSDLRKHERT
   301  HLGDKPYGCL LCGKAFSKCS YLRQHERTHN GEKPYECHLC GKAFSHCSHL RQHERSHNGE
   361  KPHGCHLCGK AFTESSVLKR HERIHTGEKP YECHVCGKAF TESSDLRRHE RTHTGEKPYE
   421  CHLCGKAFNH SSVLRRHERT HTGEKPYECN ICGKAFNRSY NFRLHRRVHT GEKPYVCPLC
   481  GKAFSKFFNL RQHERTHTKK AMNM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF596 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • retina: 17 nTPM
  • testis: 15 nTPM
  • cerebellum: 9.4 nTPM
  • endometrium: 6.6 nTPM
  • epididymis: 6.6 nTPM
  • thyroid gland: 5.4 nTPM

Single-cell type

  • epicardial cells: 200 nCPM
  • late primary spermatocytes: 131 nCPM
  • cardiomyocytes: 81 nCPM
  • early spermatids: 47 nCPM
  • mesothelial cells: 39 nCPM
  • sertoli cells: 30 nCPM

Immune cell

  • basophil: 4.7 nTPM
  • naive B-cell: 3.6 nTPM
  • naive CD8 T-cell: 3.4 nTPM
  • memory B-cell: 3.2 nTPM
  • MAIT T-cell: 3.1 nTPM
  • naive CD4 T-cell: 2.9 nTPM

Brain region

  • cerebellum: 19 nTPM
  • white matter: 16 nTPM
  • hypothalamus: 13 nTPM
  • cerebral cortex: 12 nTPM
  • choroid plexus: 11 nTPM
  • thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0
gnomAD missense Z
-2.55
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF596 as an antibody target. Whether an autoantibody or antibody against ZNF596 could matter depends on whether native ZNF596 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF596 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF596 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF596. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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