Seroatlas · Human Serome Atlas

ZNF595

Zinc finger protein 595

Also known as: FLJ31740, ZN595_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYB9
Gene: ZNF595
Ensembl: ENSG00000272602
Chromosome: 4
Canonical length: 648 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein belonging to the Cys2His2 zinc finger protein family, whose members function as transcription factors that can regulate a broad variety of developmental and cellular processes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Canonical amino-acid sequenceUniProt

648 residues, UniProt reviewed canonical sequence.

>Q8IYB9|ZNF595
     1  MELVTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLGFVISNP DLVTCLEQIK
    61  EPCNLKIHET AAKPPAICSP FSQDLSPVQG IEDSFHKLIL KRYEKCGHEN LQLRKGCKRV
   121  NECKVQKGVN NGVYQCLSTT QSKIFQCNTC VKVFSKFSNS NKHKIRHTGE KPFKCTECGR
   181  SFYMSHLTQH TGIHAGEKPY KCEKCGKAFN RSTSLSKHKR IHTGEKPYTC EECGKAFRRS
   241  TVLNEHKKIH TGEKPYKCEE CGKAFTRSTT LNEHKKIHTG EKPYKCKECG KAFRWSTSLN
   301  EHKNIHTGEK PYKCKECGKA FRQSRSLNEH KNIHTGEKPY TCEKCGKAFN QSSSLIIHRS
   361  IHSEQKLYKC EECGKAFTWS SSLNKHKRIH TGEKPYTCEE CGKAFYRSSH LAKHKRIHTG
   421  EKPYTCEECG KAFNQSSTLI LHKRIHSGQK PYKCEECGKA FTRSTTLNEH KKIHTGEKPY
   481  KCEECGKAFI WSASLNEHKN IHTGEKPYKC KECGKAFNQS SGLIIHRSIH SEQKLYKCEE
   541  CGKAFTRSTA LNEHKKIHSG EKPYKCKECG KAYNLSSTLT KHKRIHTGEK PFTCEECGKA
   601  FNWSSSLTKH KIIHTGEKSY KCEECGKAFN RPSTLTVHKR IHTGKEHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF595 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

placenta: 57 nTPM
ovary: 13 nTPM
smooth muscle: 10 nTPM
endometrium: 10 nTPM
thymus: 9.9 nTPM
thyroid gland: 9.7 nTPM

Single-cell type

thymocytes: 62 nCPM
sertoli cells: 56 nCPM
thyrotrophs: 44 nCPM
lactotrophs: 42 nCPM
corticotrophs: 40 nCPM
nk-cells: 40 nCPM

Immune cell

NK-cell: 23 nTPM
naive B-cell: 17 nTPM
memory B-cell: 16 nTPM
eosinophil: 16 nTPM
plasmacytoid DC: 16 nTPM
gdT-cell: 8.5 nTPM

Brain region

cerebellum: 34 nTPM
pons: 24 nTPM
cerebral cortex: 23 nTPM
white matter: 22 nTPM
medulla oblongata: 21 nTPM
hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0.31
gnomAD missense Z: 1.6

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF595 as an antibody target. Whether an autoantibody or antibody against ZNF595 could matter depends on whether native ZNF595 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF595 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF595 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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