Seroatlas · Human Serome Atlas

ZNF594

Zinc finger protein 594

Also known as: KIAA1871, ZN594_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JF6
Gene: ZNF594
Ensembl: ENSG00000180626
Chromosome: 17
Canonical length: 807 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

807 residues, UniProt reviewed canonical sequence.

>Q96JF6|ZNF594
     1  MKEWKSKMEI SEEKKSARAA SEKLQRQITQ ECELVETSNS EDRLLKHWVS PLKDAMRHLP
    61  SQESGIREMH IIPQKAIVGE IGHGCNEGEK ILSAGESSHR YEVSGQNFKQ KSGLTEHQKI
   121  HNINKTYECK ECEKTFNRSS NLIIHQRIHT GNKPYVCNEC GKDSNQSSNL IIHQRIHTGK
   181  KPYICHECGK DFNQSSNLVR HKQIHSGGNP YECKECGKAF KGSSNLVLHQ RIHSRGKPYL
   241  CNKCGKAFSQ STDLIIHHRI HTGEKPYECY DCGQMFSQSS HLVPHQRIHT GEKPLKCNEC
   301  EKAFRQHSHL TEHQRLHSGE KPYECHRCGK TFSGRTAFLK HQRLHAGEKI EECEKTFSKD
   361  EELREEQRIH QEEKAYWCNQ CGRNFQGTSD LIRHQVTHTG EKPYECKECG KTFNQSSDLL
   421  RHHRIHSGEK PCVCSKCGKS FRGSSDLIRH HRVHTGEKPY ECSECGKAFS QRSHLVTHQK
   481  IHTGEKPYQC TECGKAFRRR SLLIQHRRIH SGEKPYECKE CGKLFIWRTA FLKHQSLHTG
   541  EKLECEKTFS QDEELRGEQK IHQEAKAYWC NQCGRAFQGS SDLIRHQVTH TREKPYECKE
   601  CGKTFNQSSD LLRHHRIHSG EKPYVCNKCG KSFRGSSDLI KHHRIHTGEK PYECSECGKA
   661  FSQRSHLATH QKIHTGEKPY QCSECGNAFR RRSLLIQHRR LHSGEKPYEC KECGKLFMWH
   721  TAFLKHQRLH AGEKLEECEK TFSKDEELRK EQRTHQEKKV YWCNQCSRTF QGSSDLIRHQ
   781  VTHTREKPYE CKECGKTQSE LRPSETS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF594 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

retina: 11 nTPM
ovary: 7.2 nTPM
cerebellum: 5.8 nTPM
lymph node: 5.8 nTPM
pituitary gland: 5.8 nTPM
tonsil: 5.5 nTPM

Single-cell type

myonuclei: 46 nCPM
adrenal cortex cells: 41 nCPM
choroid plexus epithelial cells: 41 nCPM
thyrotrophs: 39 nCPM
lactotrophs: 37 nCPM
somatotrophs: 35 nCPM

Immune cell

naive B-cell: 2.5 nTPM
T-reg: 2.4 nTPM
naive CD4 T-cell: 2.3 nTPM
plasmacytoid DC: 2.2 nTPM
memory B-cell: 1.6 nTPM
naive CD8 T-cell: 1.6 nTPM

Brain region

white matter: 26 nTPM
cerebellum: 25 nTPM
choroid plexus: 22 nTPM
medulla oblongata: 21 nTPM
basal ganglia: 21 nTPM
cerebral cortex: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: -2.5
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF594 as an antibody target. Whether an autoantibody or antibody against ZNF594 could matter depends on whether native ZNF594 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF594 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF594 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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