Seroatlas · Human Serome Atlas

ZNF593OS

Transmembrane protein ZNF593OS

Also known as: ZNOS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0U1RRA0
Gene
ZNF593OS
Ensembl
ENSG00000236782
Chromosome
1
Canonical length
63 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

63 residues, UniProt reviewed canonical sequence.

>A0A0U1RRA0|ZNF593OS
     1  MRFRRLTPGY FRVLQMQVAG ELKAEPRSLL AGVVATVLAV LGLGGSCYAV WKMVGQRRVP
    61  RAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF593OS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • retina: 20 nTPM
  • skeletal muscle: 3.5 nTPM
  • cerebellum: 2.5 nTPM
  • ovary: 1.5 nTPM
  • endometrium: 1 nTPM
  • hypothalamus: 1 nTPM

Single-cell type

  • retinal horizontal cells: 228 nCPM
  • müller glia: 163 nCPM
  • retinal amacrine cells: 126 nCPM
  • ocular epithelial cells: 121 nCPM
  • epicardial cells: 91 nCPM
  • retinal bipolar cells: 88 nCPM

Immune cell

  • naive B-cell: 0.9 nTPM
  • plasmacytoid DC: 0.9 nTPM
  • T-reg: 0.8 nTPM
  • memory B-cell: 0.7 nTPM
  • memory CD4 T-cell: 0.7 nTPM
  • naive CD4 T-cell: 0.7 nTPM

Brain region

  • cerebellum: 8.8 nTPM
  • white matter: 6.6 nTPM
  • cerebral cortex: 5.5 nTPM
  • basal ganglia: 5 nTPM
  • pons: 4.6 nTPM
  • hypothalamus: 4.5 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF593OS as an antibody target. Whether an autoantibody or antibody against ZNF593OS could matter depends on whether native ZNF593OS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF593OS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF593OS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF593OS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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