ZNF593
Zinc finger protein 593
Also known as: ZN593_HUMAN, ZT86
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O00488
- Gene
- ZNF593
- Ensembl
- ENSG00000142684
- Chromosome
- 1
- Canonical length
- 134 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Enables preribosome binding activity and zinc ion binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
134 residues, UniProt reviewed canonical sequence.
>O00488|ZNF593
1 MGRSRRTGAH RAHSLARQMK AKRRRPDLDE IHRELRPQGS ARPQPDPNAE FDPDLPGGGL
61 HRCLACARYF IDSTNLKTHF RSKDHKKRLK QLSVEPYSQE EAERAAGMGS YVPPRRLAVP
121 TEVSTEVPEM DTSTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF593 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 105 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 105 nTPM
- liver: 67 nTPM
- pancreas: 64 nTPM
- kidney: 43 nTPM
- stomach: 41 nTPM
- choroid plexus: 40 nTPM
Single-cell type
- oocytes: 553 nCPM
- syncytiotrophoblasts: 283 nCPM
- gastric progenitor cells: 251 nCPM
- hepatocytes: 235 nCPM
- esophageal basal cells: 226 nCPM
- extravillous trophoblasts: 177 nCPM
Immune cell
- non-classical monocyte: 71 nTPM
- plasmacytoid DC: 71 nTPM
- intermediate monocyte: 69 nTPM
- memory B-cell: 64 nTPM
- naive B-cell: 64 nTPM
- T-reg: 59 nTPM
Brain region
- hypothalamus: 25 nTPM
- pons: 24 nTPM
- midbrain: 23 nTPM
- cerebral cortex: 22 nTPM
- cerebellum: 21 nTPM
- white matter: 21 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.69
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.75
- DepMap mean gene effect
- -0.46
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- positive regulation of transcription by RNA polymerase II
- ribosome biogenesis
- negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF593 as an antibody target. Whether an autoantibody or antibody against ZNF593 could matter depends on whether native ZNF593 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF593 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF593 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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