ZNF589
Zinc finger protein 589
Also known as: SZF1, ZN589_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86UQ0
- Gene
- ZNF589
- Ensembl
- ENSG00000164048
- Chromosome
- 3
- Canonical length
- 364 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
364 residues, UniProt reviewed canonical sequence.
>Q86UQ0|ZNF589
1 MWAPREQLLG WTAEALPAKD SAWPWEEKPR YLGPVTFEDV AVLFTEAEWK RLSLEQRNLY
61 KEVMLENLRN LVSLAESKPE VHTCPSCPLA FGSQQFLSQD ELHNHPIPGF HAGNQLHPGN
121 PCPEDQPQSQ HPSDKNHRGA EAEDQRVEGG VRPLFWSTNE RGALVGFSSL FQRPPISSWG
181 GNRILEIQLS PAQNASSEEV DRISKRAETP GFGAVTFGEC ALAFNQKSNL FRQKAVTAEK
241 SSDKRQSQVC RECGRGFSRK SQLIIHQRTH TGEKPYVCGE CGRGFIVESV LRNHLSTHSG
301 EKPYVCSHCG RGFSCKPYLI RHQRTHTREK SFMCTVCGRG FREKSELIKH QRIHTGDKPY
361 VCRDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF589 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 23 nTPM
Expression across tissuesHPA
Tissue
- spleen: 23 nTPM
- epididymis: 19 nTPM
- cerebellum: 18 nTPM
- prostate: 18 nTPM
- thyroid gland: 16 nTPM
- small intestine: 15 nTPM
Single-cell type
- pdcs: 60 nCPM
- brain excitatory neurons: 54 nCPM
- cone photoreceptor cells: 54 nCPM
- retinal pigment epithelial cells: 51 nCPM
- cardiomyocytes: 49 nCPM
- prostatic glandular cells: 48 nCPM
Immune cell
- plasmacytoid DC: 11 nTPM
- memory CD8 T-cell: 3.8 nTPM
- naive CD4 T-cell: 3.8 nTPM
- naive CD8 T-cell: 3.8 nTPM
- MAIT T-cell: 3.5 nTPM
- memory CD4 T-cell: 3.4 nTPM
Brain region
- cerebellum: 34 nTPM
- cerebral cortex: 26 nTPM
- hippocampal formation: 26 nTPM
- white matter: 23 nTPM
- basal ganglia: 23 nTPM
- hypothalamus: 23 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.51
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.06
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF589 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF589 as an antibody target. Whether an autoantibody or antibody against ZNF589 could matter depends on whether native ZNF589 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF589 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF589 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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