ZNF587B
Zinc finger protein 587B
Also known as: Z587B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- E7ETH6
- Gene
- ZNF587B
- Ensembl
- ENSG00000269343
- Chromosome
- 19
- Canonical length
- 402 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
402 residues, UniProt reviewed canonical sequence.
>E7ETH6|ZNF587B
1 MAVVATLRLS AQGTVTFEDV AVKFTQEEWN LLSEAQRCLY RDVTLENLAL MSSLGCWCGV
61 EDEAAPSKQS IYIQRETQVR TPVTGVSPKK AHPCEMCGPI LGDILHVADH QGTHHKQKLH
121 RCEAWGNKLY DSGNFHQHQN EHIGEKPYRG SVEEALFVKR CKLHVSGESS VFSESGKDFL
181 PRSGLLQQEA SHTGEKSNSK TECVSPFQCG GAHYSHGDSM KHFSTKHILS QHQRLLPREE
241 CYVCCECGKS FSKYVSFSNH QRVHSGKRPY ECGECEKSFS QKSSLIQHQQ FHTGGKPYGC
301 EECGKYFSLE GYLRRHQKVH AGKGPYECGE CGKSFSSNVN LKSHQRIHTG ERPYKCGECE
361 KSFSRKPSLS YHQRFGRPRW VDHKDRKEFK TSLGNIVKSC LFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF587B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 9.3 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 9.3 nTPM
- bone marrow: 8.9 nTPM
- liver: 5.9 nTPM
- skin: 5.5 nTPM
- spleen: 5.5 nTPM
- duodenum: 5.4 nTPM
Single-cell type
- medullary thymic epithelial cells: 4.8 nCPM
- late primary spermatocytes: 1.5 nCPM
- sertoli cells: 1.1 nCPM
- early spermatids: 0.9 nCPM
- lacrimal acinar cells: 0.9 nCPM
- mucous neck cells: 0.8 nCPM
Immune cell
- neutrophil: 3 nTPM
- basophil: 2 nTPM
- classical monocyte: 1.8 nTPM
- total PBMC: 1.8 nTPM
- intermediate monocyte: 1.6 nTPM
- naive CD4 T-cell: 1.6 nTPM
Brain region
- cerebellum: 16 nTPM
- choroid plexus: 16 nTPM
- basal ganglia: 11 nTPM
- hypothalamus: 11 nTPM
- cerebral cortex: 11 nTPM
- hippocampal formation: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.81
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.45
- DepMap mean gene effect
- 0.24
- DepMap dependency class
- none
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF587B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF587B as an antibody target. Whether an autoantibody or antibody against ZNF587B could matter depends on whether native ZNF587B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF587B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF587B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...