Seroatlas · Human Serome Atlas

ZNF587

Zinc finger protein 587

Also known as: FLJ14710, FLJ20813, UBF-fl, ZF6, ZN587_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96SQ5
Gene: ZNF587
Ensembl: ENSG00000198466
Chromosome: 19
Canonical length: 575 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q96SQ5|ZNF587
     1  MAAAVPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL ISSLGCWCGS
    61  KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI LEDVFHFADH QETHHKQKLN
   121  RSGACGKNLD DTAYLHQHQK QHIGEKFYRK SVREASFVKK RKLRVSQEPF VFREFGKDVL
   181  PSSGLCQEEA AVEKTDSETM HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY
   241  VCSDCGKSFS RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGQTAYPCEE
   301  CGKSFSQKGS LISHQLVHTG EGPYECRECG KSFGQKGNLI QHQQGHTGER AYHCGECGKS
   361  FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVHHQR GHTGERPYEC KECGKSFRYR
   421  SHLTEHQRLH TGERPYNCRE CGKLFNRKYH LLVHERVHTG ERPYACEVCG KLFGNKHSVT
   481  IHQRIHTGER PYECSECGKS FLSSSALHVH KRVHSGQKPY KCSECGKSFS ECSSLIKHRR
   541  IHTGERPYEC TKCGKTFQRS STLLHHQSSH RRKAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF587 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

rectum: 12 nTPM
salivary gland: 11 nTPM
retina: 11 nTPM
pituitary gland: 10 nTPM
breast: 9.4 nTPM
prostate: 8.7 nTPM

Single-cell type

choroid plexus epithelial cells: 69 nCPM
cardiomyocytes: 48 nCPM
prostatic glandular cells: 45 nCPM
somatotrophs: 43 nCPM
lacrimal acinar cells: 39 nCPM
lactotrophs: 37 nCPM

Immune cell

basophil: 1.3 nTPM
neutrophil: 1.2 nTPM
naive B-cell: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM
T-reg: 0.7 nTPM
classical monocyte: 0.5 nTPM

Brain region

choroid plexus: 18 nTPM
white matter: 14 nTPM
cerebellum: 14 nTPM
cerebral cortex: 13 nTPM
amygdala: 13 nTPM
hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0.05
gnomAD missense Z: -0.78
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF587 as an antibody target. Whether an autoantibody or antibody against ZNF587 could matter depends on whether native ZNF587 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF587 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF587 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...