Seroatlas · Human Serome Atlas

ZNF585B

Zinc finger protein 585B

Also known as: FLJ14928, SZFP41, Z585B_HUMAN, Zfp27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q52M93
Gene: ZNF585B
Ensembl: ENSG00000245680
Chromosome: 19
Canonical length: 769 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytoplasmic bodies

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

769 residues, UniProt reviewed canonical sequence.

>Q52M93|ZNF585B
     1  MPASWTSPQK SSALAPEDHG SSYEGSVSFR DVAIDFSREE WRHLDLSQRN LYRDVMLETY
    61  SHLLSVGYQV PKPEVVMLEQ GKEPWALQGE RPRHSCPGEK LWDHNQHRKI IGYKPASSQD
   121  QKIYSGEKSY ECAEFGKSFT WKSQFKVHLK VPTGEKLYVC IECGRAFVQK PEFITHQKTH
   181  MREKPYKCNE CGKSFFQVSS LFRHHRIHTG EKLYECSECG KGFPYNSDLS IHEKIHTGER
   241  HHECTDCGKA FTQKSTLKIH QKIHTGERSY ICIECGQAFI QKTQLIAHRR IHSGEKPYEC
   301  NNCGKSFISK SQLQVHQRVH TRVKPYICTE YGKVFSNNSN LITHEKIQSR EKSSICTECG
   361  KAFTYRSELI IHQRIHTGEK PYECSDCGRA FTQKSALTVH QRIHTGEKSY ICMKCGLAFI
   421  RKAHLITHQI IHTGEKPYKC GHCGKLFTSK SQLHVHKRIH TGEKPYVCNK CGKAFTNRSN
   481  LITHQKTHTG EKSYICSKCG KAFTQRSDLI THQRIHTGEK PYECNTCGKA FTQKSNLNIH
   541  QKIHTGERQY ECHECGKAFN QKSILIVHQK IHTGEKPYVC TECGRAFIRK SNFITHQRIH
   601  TGEKPYECSD CGKSFTSKSQ LLVHQPVHTG EKPYVCAECG KAFSGRSNLS KHQKTHTGEK
   661  PYICSECGKT FRQKSELITH HRIHTGEKPY ECSDCGKSFT KKSQLQVHQR IHTGEKPYVC
   721  AECGKAFSNR SNLNKHQTTH TGDKPYKCGI CGKGFVQKSV FSVHQSSHA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF585B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 7.8 nTPM

Expression across tissuesHPA

Tissue

retina: 7.8 nTPM
liver: 7.2 nTPM
parathyroid gland: 7 nTPM
thyroid gland: 6.2 nTPM
pituitary gland: 6 nTPM
epididymis: 5.9 nTPM

Single-cell type

early spermatids: 16 nCPM
cardiomyocytes: 15 nCPM
tuft cells: 12 nCPM
epididymal principal cells: 8.3 nCPM
parietal cells: 7.1 nCPM
oligodendrocytes: 5.4 nCPM

Immune cell

basophil: 2.2 nTPM
naive CD8 T-cell: 2.2 nTPM
non-classical monocyte: 2 nTPM
naive CD4 T-cell: 1.8 nTPM
MAIT T-cell: 1.7 nTPM
gdT-cell: 1.5 nTPM

Brain region

midbrain: 17 nTPM
hypothalamus: 17 nTPM
cerebellum: 16 nTPM
cerebral cortex: 15 nTPM
pons: 15 nTPM
white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF585B as an antibody target. Whether an autoantibody or antibody against ZNF585B could matter depends on whether native ZNF585B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF585B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF585B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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