Seroatlas · Human Serome Atlas

ZNF585A

Zinc finger protein 585A

Also known as: FLJ23765, Z585A_HUMAN, Zfp27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P3V2
Gene: ZNF585A
Ensembl: ENSG00000196967
Chromosome: 19
Canonical length: 769 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

769 residues, UniProt reviewed canonical sequence.

>Q6P3V2|ZNF585A
     1  MPANWTSPQK SSALAPEDHG SSYEGSVSFR DVAIDFSREE WRHLDPSQRN LYRDVMLETY
    61  SHLLSVGYQV PEAEVVMLEQ GKEPWALQGE RPRQSCPGEK LWDHNQCRKI LSYKQVSSQP
   121  QKMYPGEKAY ECAKFEKIFT QKSQLKVHLK VLAGEKLYVC IECGKAFVQK PEFIIHQKTH
   181  MREKPFKCNE CGKSFFQVSS LFRHQRIHTG EKLYECSQCG KGFSYNSDLS IHEKIHTGER
   241  HHECTDCGKA FTQKSTLKMH QKIHTGERSY ICIECGQAFI QKTHLIAHRR IHTGEKPYEC
   301  SNCGKSFISK SQLQVHQRVH TRVKPYICTE YGKVFSNNSN LVTHKKVQSR EKSSICTECG
   361  KAFTYRSELI IHQRIHTGEK PYECSDCGKA FTQKSALTVH QRIHTGEKSY ICMKCGLAFI
   421  QKAHLIAHQI IHTGEKPHKC GHCGKLFTSK SQLHVHKRIH TGEKPYMCNK CGKAFTNRSN
   481  LITHQKTHTG EKSYICSKCG KAFTQRSDLI THQRIHTGEK PYECNTCGKA FTQKSHLNIH
   541  QKIHTGERQY ECHECGKAFN QKSILIVHQK IHTGEKPYVC TECGRAFIRK SNFITHQRIH
   601  TGEKPYECSD CGKSFTSKSQ LLVHQPVHTG EKPYVCAECG KAFSGRSNLS KHQKTHTGEK
   661  PYICSECGKT FRQKSELITH HRIHTGEKPY ECSDCGKSFT KKSQLQVHQR IHTGEKPYVC
   721  AECGKAFTDR SNLNKHQTTH TGDKPYKCGI CGKGFVQKSV FSVHQSSHA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF585A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 13 nTPM
kidney: 12 nTPM
thymus: 12 nTPM
lymph node: 12 nTPM
breast: 11 nTPM
choroid plexus: 10 nTPM

Single-cell type

tuft cells: 12 nCPM
early spermatids: 9.3 nCPM
late spermatids: 6.5 nCPM
cardiomyocytes: 4.2 nCPM
late primary spermatocytes: 4.1 nCPM
early primary spermatocytes: 3.5 nCPM

Immune cell

basophil: 76 nTPM
eosinophil: 66 nTPM
T-reg: 45 nTPM
neutrophil: 39 nTPM
memory CD8 T-cell: 33 nTPM
naive CD4 T-cell: 32 nTPM

Brain region

cerebellum: 11 nTPM
white matter: 11 nTPM
midbrain: 11 nTPM
hypothalamus: 11 nTPM
pons: 9.3 nTPM
thalamus: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 0.82
DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF585A as an antibody target. Whether an autoantibody or antibody against ZNF585A could matter depends on whether native ZNF585A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF585A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF585A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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