Seroatlas · Human Serome Atlas

ZNF584

Zinc finger protein 584

Also known as: FLJ39899, ZN584_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVC4
Gene: ZNF584
Ensembl: ENSG00000171574
Chromosome: 19
Canonical length: 421 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q8IVC4|ZNF584
     1  MAGEAEAQLD PSLQGLVMFE DVTVYFSREE WGLLNVTQKG LYRDVMLENF ALVSSLGLAP
    61  SRSPVFTQLE DDEQSWVPSW VDVTPVSRAE ARRGFGLDGL CRVEDERAHP EHLKSYRVIQ
   121  HQDTHSEGKP RRHTEHGAAF PPGSSCGQQQ EVHVAEKLFK CSDCGKVFLK AFALLDHLIT
   181  HSEERPFRCP TGRSAFKKSA HINPRKIHTG ETAHVCNECG KAFSYPSKLR KHQKVHTGIK
   241  PFKCSDCGKT FNRKDALVLH QRIHTGERPY ECSKCGKTFS VLSTLIRHRK VHIGERPYEC
   301  TECGKFFKYN NSFILHQRVH TGERPFECKQ CGKGYVTRSG LYQHWKVHTG ERPYECSLCG
   361  KTFTTRSYRN RHQQFHTEER SYECTECGKA FKHSSTLLQH KKVHTPERRQ EDRAHGKVVS
   421  C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF584 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 9.2 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 9.2 nTPM
skin: 8.6 nTPM
heart muscle: 8.4 nTPM
choroid plexus: 8.2 nTPM
tongue: 7.8 nTPM
endometrium: 6.6 nTPM

Single-cell type

respiratory ciliated cells: 78 nCPM
cardiomyocytes: 54 nCPM
rod photoreceptor cells: 45 nCPM
epicardial cells: 41 nCPM
ependymal cells: 41 nCPM
fallopian tube ciliated cells: 40 nCPM

Immune cell

MAIT T-cell: 4.7 nTPM
T-reg: 4.7 nTPM
memory CD8 T-cell: 3.9 nTPM
memory CD4 T-cell: 3.3 nTPM
non-classical monocyte: 3.3 nTPM
naive CD8 T-cell: 3.2 nTPM

Brain region

choroid plexus: 12 nTPM
cerebral cortex: 12 nTPM
medulla oblongata: 12 nTPM
hippocampal formation: 11 nTPM
thalamus: 9.9 nTPM
basal ganglia: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 0.72
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF584 as an antibody target. Whether an autoantibody or antibody against ZNF584 could matter depends on whether native ZNF584 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF584 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF584 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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