Seroatlas · Human Serome Atlas

ZNF583

Zinc finger protein 583

Also known as: FLJ31030, ZN583_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96ND8
Gene: ZNF583
Ensembl: ENSG00000198440
Chromosome: 19
Canonical length: 569 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

569 residues, UniProt reviewed canonical sequence.

>Q96ND8|ZNF583
     1  MSKDLVTFGD VAVNFSQEEW EWLNPAQRNL YRKVMLENYR SLVSLGVSVS KPDVISLLEQ
    61  GKEPWMVKKE GTRGPCPDWE YVFKNSEFSS KQETYEESSK VVTVGARHLS YSLDYPSLRE
   121  DCQSEDWYKN QLGSQEVHLS QLIITHKEIL PEVQNKEYNK SWQTFHQDTI FDIQQSFPTK
   181  EKAHKHEPQK KSYRKKSVEM KHRKVYVEKK LLKCNDCEKV FNQSSSLTLH QRIHTGEKPY
   241  ACVECGKTFS QSANLAQHKR IHTGEKPYEC KECRKAFSQN AHLAQHQRVH TGEKPYQCKE
   301  CKKAFSQIAH LTQHQRVHTG ERPFECIECG KAFSNGSFLA QHQRIHTGEK PYVCNVCGKA
   361  FSHRGYLIVH QRIHTGERPY ECKECRKAFS QYAHLAQHQR VHTGEKPYEC KVCRKAFSQI
   421  AYLDQHQRVH TGEKPYECIE CGKAFSNSSS LAQHQRSHTG EKPYMCKECR KTFSQNAGLA
   481  QHQRIHTGEK PYECNVCGKA FSYSGSLTLH QRIHTGERPY ECKDCRKSFR QRAHLAHHER
   541  IHTMESFLTL SSPSPSTSNQ LPRPVGFIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF583 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 6.9 nTPM

Expression across tissuesHPA

Tissue

testis: 6.9 nTPM
ovary: 4.3 nTPM
cerebellum: 3.8 nTPM
parathyroid gland: 3.8 nTPM
retina: 3.7 nTPM
cerebral cortex: 3.6 nTPM

Single-cell type

early spermatids: 66 nCPM
late spermatids: 52 nCPM
late primary spermatocytes: 45 nCPM
early primary spermatocytes: 37 nCPM
brain excitatory neurons: 31 nCPM
oligodendrocyte progenitor cells: 30 nCPM

Immune cell

basophil: 9.7 nTPM
NK-cell: 6.2 nTPM
MAIT T-cell: 4.6 nTPM
naive CD4 T-cell: 4.6 nTPM
memory B-cell: 4.5 nTPM
non-classical monocyte: 3.7 nTPM

Brain region

cerebellum: 13 nTPM
hypothalamus: 11 nTPM
spinal cord: 10 nTPM
cerebral cortex: 9.9 nTPM
white matter: 9.8 nTPM
medulla oblongata: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.01
gnomAD missense Z: 2.42
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF583 as an antibody target. Whether an autoantibody or antibody against ZNF583 could matter depends on whether native ZNF583 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF583 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF583 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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