Seroatlas · Human Serome Atlas

ZNF582

Zinc finger protein 582

Also known as: FLJ30927, ZN582_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NG8
Gene: ZNF582
Ensembl: ENSG00000018869
Chromosome: 19
Canonical length: 517 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>Q96NG8|ZNF582
     1  MSLGSELFRD VAIVFSQEEW QWLAPAQRDL YRDVMLETYS NLVSLGLAVS KPDVISFLEQ
    61  GKEPWMVERV VSGGLCPVLE SRYDTKELFP KQHVYEVESP QWEIMESLTS YGLECSSFQD
   121  DWECRNQFDR QQGNPDRHFH QMIIRHEEMP TFDQHASLTF YQKIHTREKP FGYNKCRKDF
   181  WQKELLINHQ GIYTNEKPYK CKECGKAFKY GSRLIQHENI HSGKKPYECK ECGKAFNSGS
   241  NFIQHQRVHT GEKPYECKDC EKAFSRSSQL IEHQRTHTGE KPYQCKECGK AFNRISHLKV
   301  HYRIHTGEKP YACKECGKTF SHRSQLIQHQ TVHTGRKLYE CKECGKAFNQ GSTLIRHQRI
   361  HTGEKPYECK VCGKAFRVSS QLKQHQRIHT GEKPYQCKVC GRAFKRVSHL TVHYRIHTGE
   421  KPYECKECGK AFSHCSQLIH HQVIHTEKKP YEYKECEKTL SHDSTTVQPQ RMHNRETHVN
   481  IINVEKPSIS SYPLLIIREF MLASNHMNGS NGESPLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF582 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

retina: 9.4 nTPM
epididymis: 6.3 nTPM
thyroid gland: 5.9 nTPM
cerebellum: 5 nTPM
choroid plexus: 4.5 nTPM
basal ganglia: 4.4 nTPM

Single-cell type

epicardial cells: 32 nCPM
cardiomyocytes: 32 nCPM
undifferentiated spermatogonia: 18 nCPM
sertoli cells: 15 nCPM
hepatic stellate cells: 13 nCPM
lactotrophs: 13 nCPM

Immune cell

NK-cell: 5.9 nTPM
eosinophil: 3.6 nTPM
memory B-cell: 3.5 nTPM
MAIT T-cell: 3.3 nTPM
memory CD4 T-cell: 2.7 nTPM
basophil: 2.6 nTPM

Brain region

cerebellum: 11 nTPM
white matter: 9.5 nTPM
hypothalamus: 9.2 nTPM
basal ganglia: 8.9 nTPM
medulla oblongata: 8.3 nTPM
choroid plexus: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF582 as an antibody target. Whether an autoantibody or antibody against ZNF582 could matter depends on whether native ZNF582 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF582 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF582 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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