Seroatlas · Human Serome Atlas

ZNF580

Zinc finger protein 580

Also known as: ZN580_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UK33
Gene: ZNF580
Ensembl: ENSG00000213015
Chromosome: 19
Canonical length: 172 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of cell migration; and positive regulation of interleukin-8 production. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>Q9UK33|ZNF580
     1  MLLLPPRPPH PRSSSPEAMD PPPPKAPPFP KAEGPSSTPS SAAGPRPPRL GRHLLIDANG
    61  VPYTYTVQLE EEPRGPPQRE APPGEPGPRK GYSCPECARV FASPLRLQSH RVSHSDLKPF
   121  TCGACGKAFK RSSHLSRHRA THRARAGPPH TCPLCPRRFQ DAAELAQHVR LH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF580 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 68 nTPM
thyroid gland: 64 nTPM
prostate: 59 nTPM
endometrium: 58 nTPM
kidney: 57 nTPM
ovary: 55 nTPM

Single-cell type

tuft cells: 12 nCPM
adipocytes: 8.8 nCPM
hematopoietic stem cells: 6.3 nCPM
parietal cells: 5.3 nCPM
b-cells: 3.4 nCPM
mast cells: 3.2 nCPM

Immune cell

naive B-cell: 12 nTPM
eosinophil: 12 nTPM
non-classical monocyte: 9.9 nTPM
memory B-cell: 8.5 nTPM
neutrophil: 6 nTPM
intermediate monocyte: 5.1 nTPM

Brain region

medulla oblongata: 86 nTPM
hypothalamus: 85 nTPM
amygdala: 83 nTPM
cerebral cortex: 83 nTPM
midbrain: 80 nTPM
hippocampal formation: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0.53
gnomAD missense Z: 1.09
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF580 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SMAD2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF580 as an antibody target. Whether an autoantibody or antibody against ZNF580 could matter depends on whether native ZNF580 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF580 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF580 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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