Seroatlas · Human Serome Atlas

ZNF579

Zinc finger protein 579

Also known as: FLJ35453, ZN579_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NAF0
Gene: ZNF579
Ensembl: ENSG00000218891
Chromosome: 19
Canonical length: 562 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

562 residues, UniProt reviewed canonical sequence.

>Q8NAF0|ZNF579
     1  MDPQPPPPAQ GSPPHRGRGR GRGRGRGRGR GRGRGGAGAP RAPLPCPTCG RLFRFPYYLS
    61  RHRLSHSGLR PHACPLCPKA FRRPAHLSRH LRGHGPQPPL RCAACPRTFP EPAQLRRHLA
   121  QEHAGGEVEL AIERVAKETA EPSWGPQDEG SEPPTTAAAG ATEEEAVAAW PETWPAGEPS
   181  TLAAPTSAAE PRESESEEAE AGAAELRAEL ALAAGRQEEK QVLLQADWTL LCLRCREAFA
   241  TKGELKAHPC LRPEGEQEGE GGPPPRPKRH QCSICLKAFA RPWSLSRHRL VHSTDRPFVC
   301  PDCGLAFRLA SYLRQHRRVH GPLSLLAPLP AAGKKDDKAS GARNSAKGPE GGEGAECGGA
   361  SEGGEGQNGG DAAPARPPAG EPRFWCPECG KGFRRRAHLR QHGVTHSGAR PFQCVRCQRE
   421  FKRLADLARH AQVHAGGPAP HPCPRCPRRF SRAYSLLRHQ RCHRAELERA AALQALQAQA
   481  PTSPPPPPPP LKAEQEEEGL PLPLANIKEE PPSPGTPPQS PPAPPVFLSA SCFDSQDHSA
   541  FEMEEEEVDS KAHLRGLGGL AS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF579 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 32 nTPM
skeletal muscle: 32 nTPM
stomach: 20 nTPM
thyroid gland: 16 nTPM
kidney: 15 nTPM
pancreas: 15 nTPM

Single-cell type

cholangiocytes: 24 nCPM
pancreatic islet cells: 23 nCPM
alveolar cells type 1: 23 nCPM
fallopian secretory cells: 21 nCPM
pancreatic duct cells: 18 nCPM
fallopian tube ciliated cells: 18 nCPM

Immune cell

myeloid DC: 0.3 nTPM
classical monocyte: 0.2 nTPM
naive B-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
basophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

cerebellum: 40 nTPM
medulla oblongata: 30 nTPM
midbrain: 28 nTPM
pons: 27 nTPM
cerebral cortex: 26 nTPM
thalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.84
gnomAD missense Z: 2.46
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF579 as an antibody target. Whether an autoantibody or antibody against ZNF579 could matter depends on whether native ZNF579 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF579 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF579 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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