Seroatlas · Human Serome Atlas

ZNF578

Zinc finger protein 578

Also known as: FLJ31384, ZN578_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96N58
Gene: ZNF578
Ensembl: ENSG00000258405
Chromosome: 19
Canonical length: 590 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

590 residues, UniProt reviewed canonical sequence.

>Q96N58|ZNF578
     1  MLHEEAAQKR KGKEPGMALP QGRLTFRDVA IEFSLAEWKF LNPAQRALYR EVMLENYRNL
    61  EAVDISSKRM MKEVLSTGQG NTEVIHTGML QRHESYHTGD FCFQEIEKDI HDFEFQSQKD
   121  ERNGHEASMP KIKELMGSTD RHDQRHAGNK PIKDQLGLSF HLHLPELHIF QPEEKIANQV
   181  EKSVNDASSI STSQRISCRP ETHTPNNYGN NFFHSSLLTQ KQEVHMREKS FQCNETGEAF
   241  NCSSFVRKHQ IIHLGEKQYK FDICGKVFNE KRYLARHRRC HTSEKPYKCN ECGKSFSYKS
   301  SLTCHRRCHT GEKPYKCNEC GKSFSYKSSL TCHHRCHTGE KPYKCNECGK SFSYKSSLRC
   361  HRRLHTGIKP YKCNECGKMF GQNSTLVIHK AIHTGEKPYK CNECGKAFNQ QSHLSRHHRL
   421  HTGEKPYKCN DCGKAFIHQS SLARHHRLHT GEKSYKCEEC DRVFSQKSNL ERHKIIHTGE
   481  KPYKCNECHK TFSHRSSLPC HRRLHSGEKP YKCNECGKTF NVQSHLSRHH RLHTGEKPYK
   541  CKVCDKAFMC HSYLANHTRI HSGEKPYKCN ECGKAHNHLI DSSIKPCMSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF578 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 5.9 nTPM

Expression across tissuesHPA

Tissue

testis: 5.9 nTPM
retina: 2.8 nTPM
epididymis: 1.7 nTPM
thyroid gland: 1.6 nTPM
ovary: 1.4 nTPM
basal ganglia: 1.3 nTPM

Single-cell type

early spermatids: 77 nCPM
late spermatids: 61 nCPM
late primary spermatocytes: 36 nCPM
undifferentiated spermatogonia: 32 nCPM
cone photoreceptor cells: 27 nCPM
differentiating spermatogonia: 22 nCPM

Immune cell

basophil: 1.4 nTPM
NK-cell: 1.1 nTPM
gdT-cell: 0.9 nTPM
MAIT T-cell: 0.7 nTPM
naive B-cell: 0.7 nTPM
naive CD8 T-cell: 0.6 nTPM

Brain region

cerebellum: 13 nTPM
basal ganglia: 9 nTPM
hypothalamus: 8.9 nTPM
white matter: 8.8 nTPM
thalamus: 8 nTPM
medulla oblongata: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -0.8
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF578 as an antibody target. Whether an autoantibody or antibody against ZNF578 could matter depends on whether native ZNF578 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF578 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF578 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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