Seroatlas · Human Serome Atlas

ZNF577

Zinc finger protein 577

Also known as: MGC4400, ZN577_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSK1
Gene: ZNF577
Ensembl: ENSG00000161551
Chromosome: 19
Canonical length: 485 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q9BSK1|ZNF577
     1  MKNATIVMSV RREQGSSSGE GSLSFEDVAV GFTREEWQFL DQSQKVLYKE VMLENYINLV
    61  SIGYRGTKPD SLFKLEQGEP PGIAEGAAHS QICPGFVIQS RRYAGKDSDA FGGYGRSCLH
   121  IKRDKTLTGV KYHRCVKPSS PKSQLNDLQK ICAGGKPHEC SVCGRAFSRK AQLIQHQRTE
   181  RGEKPHGCGE CGKTFMRKIQ LTEHQRTHTG EKPHECSECG KAFSRKSQLM VHQRTHTGEK
   241  PYRCSKCGKA FSRKCRLNRH QRSHTGEKLY GCSVCGKAFS QKAYLTAHQR LHTGDKPYKC
   301  SDCGRTFYFK SDLTRHQRIH TGEKPYECSE CEKAFRSKSK LIQHQRTHTG ERPYSCRECG
   361  KAFAHMSVLI KHEKTHIRET AINSLTVEKP SSRSHTSLYM SELIQEQKTV NTVPIEMPSS
   421  GTPPLLNKSE RLVGRNVVIV EQPFPRNQAF VVNQEFEQRI SLTNEVNVAP SVINYILYLT
   481  DIVSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF577 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 26 nTPM
ovary: 18 nTPM
testis: 17 nTPM
kidney: 13 nTPM
retina: 12 nTPM
prostate: 12 nTPM

Single-cell type

late spermatids: 98 nCPM
early spermatids: 83 nCPM
cdc: 73 nCPM
sertoli cells: 71 nCPM
macrophages: 68 nCPM
oligodendrocytes: 63 nCPM

Immune cell

memory B-cell: 7 nTPM
basophil: 4.3 nTPM
eosinophil: 3.4 nTPM
NK-cell: 3.2 nTPM
naive B-cell: 3.1 nTPM
MAIT T-cell: 2.7 nTPM

Brain region

white matter: 31 nTPM
hypothalamus: 25 nTPM
basal ganglia: 22 nTPM
cerebellum: 22 nTPM
medulla oblongata: 22 nTPM
cerebral cortex: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF577 as an antibody target. Whether an autoantibody or antibody against ZNF577 could matter depends on whether native ZNF577 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF577 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF577 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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