Seroatlas · Human Serome Atlas

ZNF573

Zinc finger protein 573

Also known as: FLJ30921, ZN573_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YE8
Gene: ZNF573
Ensembl: ENSG00000189144
Chromosome: 19
Canonical length: 665 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

665 residues, UniProt reviewed canonical sequence.

>Q86YE8|ZNF573
     1  MFPVLEPHQV GLIRSYNSKT MTCFQELVTF RDVAIDFSRQ EWEYLDPNQR DLYRDVMLEN
    61  YRNLVSLGGH SISKPVVVDL LERGKEPWMI LREETQFTDL DLQCEIISYI EVPTYETDIS
   121  STQLQSIYKR EKLYECKKCQ KKFSSGYQLI LHHRFHVIER PYECKECGKN FRSGYQLTLH
   181  QRFHTGEKPY ECTECGKNFR SGYQLTVHQR FHTGEKTYEC RQCGKAFIYA SHIVQHERIH
   241  TGGKPYECQE CGRAFSQGGH LRIHQRVHTG EKPYKCKECG KTFSRRSNLV EHGQFHTDEK
   301  PYICEKCGKA FRRGHQLTVH QRVHTGKKPY ECKECGKGYT TASYFLLHQR IHKGGKPYEC
   361  KECKKTFTLY RNLTRHQNIH TGEKLFECKQ CGKTYTTGSK LFQHQKTHTG EKPYECKECG
   421  KAFSLYGYLK QHQKIHTGMK HFECKECKKT FTLYRNLTRH QNIHTGKKLF ECQECGKAYS
   481  TGSNLIQHRK THTGEKPYKC KECGKTFSLH GYLNQHQKIH TGMKPYECKV CRKTFTFYRN
   541  LTLHQSIHTD EKPFECKECG KTFRRSSHLT AHQSIHADKK PYECKECGKA FKMYGYLTQH
   601  QKIHTGGKPY ECKECGKAFS RASNLVQHER IHTGEKPYVC KQCGKTFRYG SALKAHQRIH
   661  RSIKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF573 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 2.7 nTPM

Expression across tissuesHPA

Tissue

epididymis: 2.7 nTPM
retina: 2.3 nTPM
thyroid gland: 2.3 nTPM
skin: 2 nTPM
stomach: 1.9 nTPM
bone marrow: 1.8 nTPM

Single-cell type

late spermatids: 452 nCPM
early spermatids: 221 nCPM
somatotrophs: 108 nCPM
lactotrophs: 78 nCPM
late primary spermatocytes: 75 nCPM
adrenal medulla cells: 75 nCPM

Immune cell

naive B-cell: 2.8 nTPM
naive CD4 T-cell: 2.6 nTPM
basophil: 2.1 nTPM
memory CD8 T-cell: 2.1 nTPM
gdT-cell: 2 nTPM
naive CD8 T-cell: 2 nTPM

Brain region

cerebellum: 15 nTPM
hypothalamus: 11 nTPM
white matter: 10 nTPM
cerebral cortex: 8.6 nTPM
basal ganglia: 8.4 nTPM
thalamus: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF573 as an antibody target. Whether an autoantibody or antibody against ZNF573 could matter depends on whether native ZNF573 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF573 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF573 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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