Seroatlas · Human Serome Atlas

ZNF572

Zinc finger protein 572

Also known as: FLJ38002, ZN572_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3I7
Gene: ZNF572
Ensembl: ENSG00000180938
Chromosome: 8
Canonical length: 529 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>Q7Z3I7|ZNF572
     1  MEQEKKLLVS DSNSFMERES LKSPFTGDTS MNNLETVHHN NSKADKLKEK PSEWSKRHRP
    61  QHYKHEDAKE MPLTWVQDEI WCHDSYESDG KSENWGNFIA KEEEKPNHQE WDSGEHTNAC
   121  VQQNSSFVDR PYKCSECWKS FSNSSHLRTH QRTHSGEKPY KCSECAKCFC NSSHLIQHLR
   181  MHTGEKPYQC GECGKSFSNT SHLIIHERTH TGEKPYKCPE CGKRFSSSSH LIQHHRSHTG
   241  EKPYECSVCG KGFSHSYVLI EHQRTHTGEK PYKCPDCGKS FSQSSSLIRH QRTHTGEKPY
   301  KCLECEKSFG CNSTLIKHQR IHTGEKPYQC PECGKNFSRS SNLITHQKMH TGEKSYESSE
   361  YEESLGQNCN VIEECRIQLG EKPYRCCECG KSFGLSSHLI RHQRTHTGEK PYRCSECWKT
   421  FSQSSTLVIH QRTHTGEKPY KCPDCGESFS QSFNLIRHRR THIGEKPYKC TSCEKCFSRS
   481  AYLSQHRKIH VEKPFESPDV GDFPHEWTWK NCSGEMPFIS SFSVSNSSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF572 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 3.4 nTPM

Expression across tissuesHPA

Tissue

testis: 3.4 nTPM
epididymis: 2.1 nTPM
lymph node: 1.8 nTPM
ovary: 1.8 nTPM
retina: 1.8 nTPM
tonsil: 1.8 nTPM

Single-cell type

tuft cells: 12 nCPM
megakaryocytes: 6.2 nCPM
bergmann glia: 4.3 nCPM
microglia: 3.6 nCPM
parietal cells: 3.5 nCPM
early primary spermatocytes: 3 nCPM

Immune cell

naive CD4 T-cell: 0.8 nTPM
NK-cell: 0.7 nTPM
memory B-cell: 0.6 nTPM
naive B-cell: 0.6 nTPM
naive CD8 T-cell: 0.5 nTPM
MAIT T-cell: 0.4 nTPM

Brain region

white matter: 3.6 nTPM
medulla oblongata: 3.2 nTPM
basal ganglia: 3 nTPM
spinal cord: 2.7 nTPM
midbrain: 2.6 nTPM
hypothalamus: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.01
gnomAD missense Z: 0.32
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF572 as an antibody target. Whether an autoantibody or antibody against ZNF572 could matter depends on whether native ZNF572 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF572 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF572 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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