Seroatlas · Human Serome Atlas

ZNF571

Zinc finger protein 571

Also known as: HSPC059, ZN571_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3V5
Gene: ZNF571
Ensembl: ENSG00000180479
Chromosome: 19
Canonical length: 609 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Plasma membrane

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

609 residues, UniProt reviewed canonical sequence.

>Q7Z3V5|ZNF571
     1  MPHLLVTFRD VAIDFSQEEW ECLDPAQRDL YRDVMLENYS NLISLDLESS CVTKKLSPEK
    61  EIYEMESLQW ENMGKRINHH LQYNGLGDNM ECKGNLEGQE ASQEGLYMCV KITCEEKATE
   121  SHSTSSTFHR IIPTKEKLYK CKECRQGFSY LSCLIQHEEN HNIEKCSEVK KHRNTFSKKP
   181  SYIQHQRIQT GEKPYECMEC GKAFGRTSDL IQHQKIHTNE KPYQCNACGK AFIRGSQLTE
   241  HQRVHTGEKP YECKKCGKAF SYCSQYTLHQ RIHSGEKPYE CKDCGKAFIL GSQLTYHQRI
   301  HSGEKPYECK ECGKAFILGS HLTYHQRVHT GEKPYICKEC GKAFLCASQL NEHQRIHTGE
   361  KPYECKECGK TFFRGSQLTY HLRVHSGERP YKCKECGKAF ISNSNLIQHQ RIHTGEKPYK
   421  CKECGKAFIC GKQLSEHQRI HTGEKPFECK ECGKAFIRVA YLTQHEKIHG EKHYECKECG
   481  KTFVRATQLT YHQRIHTGEK PYKCKECDKA FIYGSQLSEH QRIHRGEKPY ECKQCGKAFI
   541  RGSHLTEHLR THTGEKPYEC KECGRAFSRG SELTLHQRIH TGEKPYTCVQ CGKDFRCPSQ
   601  LTQHTRLHN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF571 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 73 nTPM
retina: 27 nTPM
breast: 14 nTPM
parathyroid gland: 11 nTPM
testis: 9.9 nTPM
epididymis: 9.4 nTPM

Single-cell type

somatotrophs: 147 nCPM
cardiomyocytes: 144 nCPM
lactotrophs: 99 nCPM
rod photoreceptor cells: 78 nCPM
thyrotrophs: 61 nCPM
oocytes: 60 nCPM

Immune cell

naive B-cell: 7.8 nTPM
memory B-cell: 7.6 nTPM
naive CD8 T-cell: 6.7 nTPM
naive CD4 T-cell: 6 nTPM
gdT-cell: 5.3 nTPM
memory CD8 T-cell: 5.3 nTPM

Brain region

cerebral cortex: 55 nTPM
cerebellum: 48 nTPM
white matter: 47 nTPM
hypothalamus: 47 nTPM
basal ganglia: 46 nTPM
amygdala: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: -0.27
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF571 as an antibody target. Whether an autoantibody or antibody against ZNF571 could matter depends on whether native ZNF571 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF571 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF571 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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