Seroatlas · Human Serome Atlas

ZNF570

Zinc finger protein 570

Also known as: FLJ30791, ZN570_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96NI8
Gene
ZNF570
Ensembl
ENSG00000171827
Chromosome
19
Canonical length
536 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>Q96NI8|ZNF570
     1  MAVGLLKAMY QELVTFRDVA VDFSQEEWDC LDSSQRHLYS NVMLENYRIL VSLGLCFSKP
    61  SVILLLEQGK APWMVKRELT KGLCSGWEPI CETEELTPKQ DFYEEHQSQK IIETLTSYNL
   121  EYSSLREEWK CEGYFERQPG NQKACFKEEI ITHEEPLFDE REQEYKSWGS FHQNPLLCTQ
   181  KIIPKEEKVH KHDTQKRSFK KNLMAIKPKS VCAEKKLLKC NDCEKVFSQS SSLTLHQRIH
   241  TGEKPYKCIE CGKAFSQRSN LVQHQRIHTG EKPYECKECR KAFSQNAHLV QHLRVHTGEK
   301  PYECKVCRKA FSQFAYLAQH QRVHTGEKPY ECIECGKAFS NRSSIAQHQR VHTGEKPYEC
   361  NVCGKAFSLR AYLTVHQRIH TGERPYECKE CGKAFSQNSH LAQHQRIHTG EKPYKCQECR
   421  KAFSQIAYLA QHQRVHTGEK PYECIECGKA FSNDSSLTQH QRVHTGEKPY ECTVCGKAFS
   481  YCGSLAQHQR IHTGERPYEC KECKKTFRQH AHLAHHQRIH IGESLSPPNP VNHQVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF570 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
5.6 nTPM

Expression across tissuesHPA

Tissue

  • testis: 5.6 nTPM
  • parathyroid gland: 3.8 nTPM
  • ovary: 3.4 nTPM
  • spinal cord: 3.4 nTPM
  • thyroid gland: 3 nTPM
  • retina: 2.9 nTPM

Single-cell type

  • early spermatids: 68 nCPM
  • late primary spermatocytes: 37 nCPM
  • cardiomyocytes: 24 nCPM
  • retinal horizontal cells: 16 nCPM
  • paneth cells: 16 nCPM
  • nk-cells: 15 nCPM

Immune cell

  • memory CD4 T-cell: 2.1 nTPM
  • naive CD8 T-cell: 1.8 nTPM
  • NK-cell: 1.8 nTPM
  • naive CD4 T-cell: 1.7 nTPM
  • memory B-cell: 1.6 nTPM
  • neutrophil: 1.4 nTPM

Brain region

  • cerebellum: 9.6 nTPM
  • white matter: 9.6 nTPM
  • midbrain: 9.1 nTPM
  • hypothalamus: 8.9 nTPM
  • basal ganglia: 8.7 nTPM
  • spinal cord: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
0.98
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF570 as an antibody target. Whether an autoantibody or antibody against ZNF570 could matter depends on whether native ZNF570 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF570 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF570 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF570. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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