Seroatlas · Human Serome Atlas

ZNF569

Zinc finger protein 569

Also known as: FLJ32053, ZAP1, Zfp74, ZN569_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5MCW4
Gene
ZNF569
Ensembl
ENSG00000196437
Chromosome
19
Canonical length
686 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

686 residues, UniProt reviewed canonical sequence.

>Q5MCW4|ZNF569
     1  MTESQGTVTF KDVAIDFTQE EWKRLDPAQR KLYRNVMLEN YNNLITVGYP FTKPDVIFKL
    61  EQEEEPWVME EEVLRRHWQG EIWGVDEHQK NQDRLLRQVE VKFQKTLTEE KGNECQKKFA
   121  NVFPLNSDFF PSRHNLYEYD LFGKCLEHNF DCHNNVKCLM RKEHCEYNEP VKSYGNSSSH
   181  FVITPFKCNH CGKGFNQTLD LIRHLRIHTG EKPYECSNCR KAFSHKEKLI KHYKIHSREQ
   241  SYKCNECGKA FIKMSNLIRH QRIHTGEKPY ACKECEKSFS QKSNLIDHEK IHTGEKPYEC
   301  NECGKAFSQK QSLIAHQKVH TGEKPYACNE CGKAFPRIAS LALHMRSHTG EKPYKCDKCG
   361  KAFSQFSMLI IHVRIHTGEK PYECNECGKA FSQSSALTVH MRSHTGEKPY ECKECRKAFS
   421  HKKNFITHQK IHTREKPYEC NECGKAFIQM SNLVRHQRIH TGEKPYICKE CGKAFSQKSN
   481  LIAHEKIHSG EKPYECNECG KAFSQKQNFI THQKVHTGEK PYDCNECGKA FSQIASLTLH
   541  LRSHTGEKPY ECDKCGKAFS QCSLLNLHMR SHTGEKPYVC NECGKAFSQR TSLIVHMRGH
   601  TGEKPYECNK CGKAFSQSSS LTIHIRGHTG EKPFDCSKCG KAFSQISSLT LHMRKHTGEK
   661  PYHCIECGKA FSQKSHLVRH QRIHTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF569 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • retina: 13 nTPM
  • testis: 10 nTPM
  • cerebellum: 5.2 nTPM
  • ovary: 5.2 nTPM
  • thyroid gland: 5.2 nTPM
  • thymus: 4.8 nTPM

Single-cell type

  • early spermatids: 202 nCPM
  • late primary spermatocytes: 112 nCPM
  • rod photoreceptor cells: 79 nCPM
  • cone photoreceptor cells: 66 nCPM
  • early primary spermatocytes: 62 nCPM
  • late spermatids: 57 nCPM

Immune cell

  • naive CD4 T-cell: 8 nTPM
  • naive CD8 T-cell: 6.5 nTPM
  • gdT-cell: 6.4 nTPM
  • memory CD8 T-cell: 6.1 nTPM
  • T-reg: 6.1 nTPM
  • eosinophil: 5.9 nTPM

Brain region

  • cerebellum: 25 nTPM
  • white matter: 23 nTPM
  • hypothalamus: 22 nTPM
  • cerebral cortex: 21 nTPM
  • midbrain: 20 nTPM
  • choroid plexus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
1.23
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF569 as an antibody target. Whether an autoantibody or antibody against ZNF569 could matter depends on whether native ZNF569 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF569 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF569 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF569. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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