Seroatlas · Human Serome Atlas

ZNF568

Zinc finger protein 568

Also known as: DKFZp686B0797, ZN568_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3ZCX4
Gene: ZNF568
Ensembl: ENSG00000198453
Chromosome: 19
Canonical length: 644 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic placenta morphogenesis and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

644 residues, UniProt reviewed canonical sequence.

>Q3ZCX4|ZNF568
     1  MTSQSSVISN SCVTMERLSH MMERKAWCSQ ESALSEEEED TTRPLETVTF KDVAVDLTQE
    61  EWEQMKPAQR NLYRDVMLEN YSNLVTVGCQ VTKPDVIFKL EQEEEPWVME EEMFGRHCPE
   121  VWEVDEQIKK QQETLVRKVT SISKKILIKE KVIECKKVAK IFPLSSDIVT SRQSFYDCDS
   181  LDKGLEHNLD LLRYEKGCVR EKQSNEFGKP FYHCASYVVT PFKCNQCGQD FSHKFDLIRH
   241  ERIHAGEKPY ECKECGKAFS RKENLITHQK IHTGEKPYKC NECGKAFIQM SNLIRHHRIH
   301  TGEKPYACKD CWKAFSQKSN LIEHERIHTG EKPYECKECG KSFSQKQNLI EHEKIHTGEK
   361  PYACNECGRA FSRMSSVTLH MRSHTGEKPY KCNKCGKAFS QCSVFIIHMR SHTGEKPYVC
   421  SECGKAFSQS SSLTVHMRNH TAEKPYECKE CGKAFSRKEN LITHQKIHTG EKPYECSECG
   481  KAFIQMSNLI RHQRIHTGEK PYACTVCGKA FSQKSNLTEH EKIHTGEKPY HCNQCGKAFS
   541  QRQNLLEHEK IHTGEKPFKC NECGKAFSRI SSLTLHVRSH TGEKPYECNK CGKAFSQCSL
   601  LIIHMRSHTG EKPFECNECG KAFSQRASLS IHKRGHTGER HQVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF568 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 8 nTPM

Expression across tissuesHPA

Tissue

retina: 8 nTPM
skeletal muscle: 7.8 nTPM
cerebellum: 6.3 nTPM
spinal cord: 5.8 nTPM
ovary: 5.7 nTPM
parathyroid gland: 5.7 nTPM

Single-cell type

choroid plexus epithelial cells: 56 nCPM
oligodendrocyte progenitor cells: 48 nCPM
bergmann glia: 47 nCPM
other brain neurons: 45 nCPM
oligodendrocytes: 44 nCPM
podocytes: 41 nCPM

Immune cell

basophil: 12 nTPM
naive CD4 T-cell: 4.8 nTPM
NK-cell: 4.8 nTPM
memory B-cell: 4.6 nTPM
gdT-cell: 4.5 nTPM
eosinophil: 4 nTPM

Brain region

cerebellum: 24 nTPM
hypothalamus: 21 nTPM
midbrain: 19 nTPM
white matter: 19 nTPM
amygdala: 17 nTPM
cerebral cortex: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 1.47
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF568 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF568 as an antibody target. Whether an autoantibody or antibody against ZNF568 could matter depends on whether native ZNF568 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF568 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF568 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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