Seroatlas · Human Serome Atlas

ZNF567

Zinc finger protein 567

Also known as: MGC45586, ZN567_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N184
Gene: ZNF567
Ensembl: ENSG00000189042
Chromosome: 19
Canonical length: 647 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

647 residues, UniProt reviewed canonical sequence.

>Q8N184|ZNF567
     1  MAQGSVSFND VTVDFTQEEW QHLDHAQKTL YMDVMLENYC HLISVGCHMT KPDVILKLER
    61  GEEPWTSFAG HTCLEENWKA EDFLVKFKEH QEKYSRSVVS INHKKLVKEK SKIYEKTFTL
   121  GKNPVNSKNL PPEYDTHGRI LKNVSELIIS NLNPARKRLS EYNGYGKSLL STKQETTHPE
   181  VKSHNQSARA FSHNEVLMQY QKTETPAQSF GYNDCEKSFL QRGGLITHSR PYKGENPSVY
   241  NKKRRATNIE KKHTCNECGK SFCRKSVLIL HQGIHSEEKP YQCHQCGNAF RRKSYLIDHQ
   301  RTHTGEKPFV CNECGKSFRL KTALTDHQRT HTGEKSYECL QCRNAFRLKS HLIRHQRTHT
   361  GEKPYECNDC GKSFRQKTTL SLHQRIHTGE KPYICKECGK SFHQKANLTV HQRTHTGEKP
   421  YICNECGKSF SQKTTLALHE KTHNEEKPYI CSECGKSFRQ KTTLVAHQRT HTGEKSYECP
   481  HCGKAFRMKS YLIDHHRTHT GEKPYECNEC GKSFSQKTNL NLHQRIHTGE KPYVCNECGK
   541  SFRQKATLTV HQKIHTGQKS YECPQCGKAF SRKSYLIHHQ RTHTGEKPYK CSECGKCFRQ
   601  KTNLIVHQRT HTGEKPYVCN ECGKSFSYKR NLIVHQRTHK GENIEMQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF567 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 8.5 nTPM

Expression across tissuesHPA

Tissue

testis: 8.5 nTPM
thymus: 6.2 nTPM
breast: 5.5 nTPM
placenta: 5.4 nTPM
parathyroid gland: 5.2 nTPM
prostate: 5 nTPM

Single-cell type

late spermatids: 177 nCPM
early spermatids: 106 nCPM
syncytiotrophoblasts: 57 nCPM
late primary spermatocytes: 48 nCPM
early primary spermatocytes: 46 nCPM
cytotrophoblasts: 34 nCPM

Immune cell

naive B-cell: 7.3 nTPM
NK-cell: 7.2 nTPM
memory CD4 T-cell: 6.4 nTPM
naive CD8 T-cell: 6.2 nTPM
naive CD4 T-cell: 6.1 nTPM
eosinophil: 6 nTPM

Brain region

cerebellum: 12 nTPM
choroid plexus: 8.1 nTPM
cerebral cortex: 7.5 nTPM
hypothalamus: 7.3 nTPM
white matter: 6.7 nTPM
hippocampal formation: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 1.67
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF567 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF567 as an antibody target. Whether an autoantibody or antibody against ZNF567 could matter depends on whether native ZNF567 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF567 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF567 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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