Seroatlas · Human Serome Atlas

ZNF566

Zinc finger protein 566

Also known as: FLJ14779, MGC12515, ZN566_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969W8
Gene
ZNF566
Ensembl
ENSG00000186017
Chromosome
19
Canonical length
418 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>Q969W8|ZNF566
     1  MAQESVMFSD VSVDFSQEEW ECLNDDQRDL YRDVMLENYS NLVSMGHSIS KPNVISYLEQ
    61  GKEPWLADRE LTRGQWPVLE SRCETKKLFL KKEIYEIEST QWEIMEKLTR RDFQCSSFRD
   121  DWECNRQFKK ELGSQGGHFN QLVFTHEDLP TLSHHPSFTL QQIINSKKKF CASKEYRKTF
   181  RHGSQFATHE IIHTIEKPYE CKECGKSFRH PSRLTHHQKI HTGKKPFECK ECGKTFICGS
   241  DLTRHHRIHT GEKPYECKEC GKAFSSGSNF TRHQRIHTGE KPYECKECGK AFSSGSNFTQ
   301  HQRIHTGEKP YECKECGNAF SQSSQLIKHQ RIHTGEKPYE CKECEKAFRS GSDLTRHQRI
   361  HTGEKPYECK ICGKAYSQSS QLISHHRIHT SEKPYEYREC GKNFNYDPQL IQHQNLYW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF566 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 11 nTPM
  • hypothalamus: 5.9 nTPM
  • spinal cord: 5.8 nTPM
  • midbrain: 5.6 nTPM
  • hippocampal formation: 5.5 nTPM
  • amygdala: 5.1 nTPM

Single-cell type

  • cardiomyocytes: 55 nCPM
  • myonuclei: 53 nCPM
  • adrenal medulla cells: 53 nCPM
  • cone photoreceptor cells: 50 nCPM
  • retinal horizontal cells: 42 nCPM
  • other brain neurons: 40 nCPM

Immune cell

  • basophil: 5 nTPM
  • MAIT T-cell: 2.8 nTPM
  • naive CD8 T-cell: 2.7 nTPM
  • memory B-cell: 2.6 nTPM
  • memory CD8 T-cell: 2.2 nTPM
  • naive CD4 T-cell: 2.2 nTPM

Brain region

  • cerebellum: 11 nTPM
  • white matter: 8.5 nTPM
  • cerebral cortex: 7.8 nTPM
  • hypothalamus: 7.8 nTPM
  • basal ganglia: 7.7 nTPM
  • midbrain: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.41
gnomAD missense Z
0.74
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF566 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF566 as an antibody target. Whether an autoantibody or antibody against ZNF566 could matter depends on whether native ZNF566 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF566 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF566 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF566. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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