Seroatlas · Human Serome Atlas

ZNF565

Zinc finger protein 565

Also known as: FLJ36991, ZN565_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9K5
Gene: ZNF565
Ensembl: ENSG00000196357
Chromosome: 19
Canonical length: 539 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

539 residues, UniProt reviewed canonical sequence.

>Q8N9K5|ZNF565
     1  MRRGPWERWS LASHRLDAGL CTCPREESRE IRAGQIVLKA MAQGLVTFRD VAIEFSLEEW
    61  KCLEPAQRDL YREVTLENFG HLASLGLSIS KPDVVSLLEQ GKEPWMIAND VTGPWCPDLE
   121  SRCEKFLQKD IFEIGAFNWE IMESLKCSDL EGSDFRADWE CEGQFERQVN EECYFKQVNV
   181  TYGHMPVFQH HTSHTVRQSR ETGEKLMECH ECGKAFSRGS HLIQHQKIHT GEKPFGCKEC
   241  GKAFSRASHL VQHQRIHTGE KPYDCKDCGK AFGRTSELIL HQRLHTGVKP YECKECGKTF
   301  RQHSQLILHQ RTHTGEKPYV CKDCGKAFIR GSQLTVHRRI HTGARPYECK ECGKAFRQHS
   361  QLTVHQRIHT GEKPYECKEC GKGFIHSSEV TRHQRIHSGE KPYECKECGK AFRQHAQLTR
   421  HQRVHTGDRP YECKDCGKAF SRSSYLIQHQ RIHTGDKPYE CKECGKAFIR VSQLTHHQRI
   481  HTCEKPYECR ECGMAFIRSS QLTEHQRIHP GIKPYECREC GQAFILGSQL IEHYRIHTG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF565 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 6.3 nTPM

Expression across tissuesHPA

Tissue

testis: 6.3 nTPM
spinal cord: 4.3 nTPM
tongue: 4.3 nTPM
ovary: 4 nTPM
skeletal muscle: 3.9 nTPM
midbrain: 3.7 nTPM

Single-cell type

cardiomyocytes: 509 nCPM
epicardial cells: 339 nCPM
myonuclei: 308 nCPM
adipocytes: 169 nCPM
oligodendrocytes: 164 nCPM
granulosa cells: 144 nCPM

Immune cell

basophil: 16 nTPM
eosinophil: 4.4 nTPM
naive CD4 T-cell: 3.6 nTPM
non-classical monocyte: 3.3 nTPM
memory CD4 T-cell: 3.2 nTPM
myeloid DC: 3.1 nTPM

Brain region

white matter: 28 nTPM
medulla oblongata: 18 nTPM
basal ganglia: 18 nTPM
pons: 17 nTPM
midbrain: 17 nTPM
cerebellum: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 1.45
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF565 as an antibody target. Whether an autoantibody or antibody against ZNF565 could matter depends on whether native ZNF565 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF565 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF565 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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