Seroatlas · Human Serome Atlas

ZNF562

Zinc finger protein 562

Also known as: FLJ20079, ZN562_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6V9R5
Gene
ZNF562
Ensembl
ENSG00000171466
Chromosome
19
Canonical length
426 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>Q6V9R5|ZNF562
     1  MSAFDMSHGF FPREPICPFE EKTKIGTMVE DHRSNSYQDS VTFDDVAVEF TPEEWALLDT
    61  TQKYLYRDVM LENYMNLASV DFFFCLTSEW EIQPRTKRSS LQQGFLKNQI FTGIQMQTRS
   121  YSGWKLCENC GEVFSEQFCL KTHMRAQNGG NTFEGNCYGK DSISVHKEAS IGQELSKFNP
   181  CGKVFTLTPG LAVHLEILNG RQPYKCKECG KGFKYFASLD NHMGIHIGEK LCEFQECERA
   241  ITTSSHLKQC VAVHTGKKSE KTKNCGKSFT NFSQLSAHAK THKGEKSFEC KECGRSFRNS
   301  SSFNVHIQIH TGIKPHKCTE CGKAFTRSTH LTQHVRTHTG IKPYECKECG QAFTQYTGLA
   361  IHIRNHTGEK PYQCKECGKA FNRSSTLTQH RRIHTGEKPY ECVECGKTFI TSSHRSKHLK
   421  THSGER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF562 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 15 nTPM
  • breast: 11 nTPM
  • urinary bladder: 8.5 nTPM
  • colon: 7.8 nTPM
  • smooth muscle: 7.5 nTPM
  • endometrium: 7.3 nTPM

Single-cell type

  • esophageal apical cells: 192 nCPM
  • urothelial cells: 94 nCPM
  • papillary tip epithelial cells: 93 nCPM
  • esophageal suprabasal cells: 77 nCPM
  • renal collecting duct principal cells: 75 nCPM
  • cardiomyocytes: 74 nCPM

Immune cell

  • non-classical monocyte: 4.5 nTPM
  • intermediate monocyte: 3.9 nTPM
  • MAIT T-cell: 3.6 nTPM
  • myeloid DC: 3.6 nTPM
  • basophil: 3.3 nTPM
  • eosinophil: 3.1 nTPM

Brain region

  • cerebellum: 48 nTPM
  • white matter: 43 nTPM
  • hypothalamus: 36 nTPM
  • thalamus: 36 nTPM
  • cerebral cortex: 36 nTPM
  • basal ganglia: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0.06
gnomAD missense Z
0.1
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF562 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF562 as an antibody target. Whether an autoantibody or antibody against ZNF562 could matter depends on whether native ZNF562 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF562 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF562 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF562. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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