Seroatlas · Human Serome Atlas

ZNF561

Zinc finger protein 561

Also known as: MGC45408, ZN561_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N587
Gene
ZNF561
Ensembl
ENSG00000171469
Chromosome
19
Canonical length
486 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

486 residues, UniProt reviewed canonical sequence.

>Q8N587|ZNF561
     1  MAAIYLSRGF FSREPICPFE EKTKVERMVE DYLASGYQDS VTFDDVAVDF TPEEWALLDT
    61  TEKYLYRDVM LENYMNLASV EWEIQPRTKR SSLQQGFLKN QIFSGIQMTR GYSGWKLCDC
   121  KNCGEVFREQ FCLKTHMRVQ NGGNTSEGNC YGKDTLSVHK EASTGQELSK FNPCGKVFTL
   181  TPGLAVHLEV LNARQPYKCK ECGKGFKYFA SLDNHMGIHT DEKLCEFQEY GRAVTASSHL
   241  KQCVAVHTGK KSKKTKKCGK SFTNFSQLYA PVKTHKGEKS FECKECGRSF RNSSCLNDHI
   301  QIHTGIKPHK CTYCGKAFTR STQLTEHVRT HTGIKPYECK ECGQAFAQYS GLSIHIRSHS
   361  GKKPYQCKEC GKAFTTSTSL IQHTRIHTGE KPYECVECGK TFITSSRRSK HLKTHSGEKP
   421  FVCKICGKAF LYSSRLNVHL RTHTGEKPFV CKECGKAFAV SSRLSRHERI HTGEKPYECK
   481  DMSVTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF561 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 24 nTPM
  • ovary: 18 nTPM
  • urinary bladder: 18 nTPM
  • fallopian tube: 18 nTPM
  • endometrium: 17 nTPM
  • seminal vesicle: 17 nTPM

Single-cell type

  • esophageal apical cells: 119 nCPM
  • esophageal suprabasal cells: 66 nCPM
  • epididymal basal cells: 62 nCPM
  • urothelial cells: 49 nCPM
  • ocular epithelial cells: 43 nCPM
  • breast myoepithelial cells: 38 nCPM

Immune cell

  • MAIT T-cell: 6.2 nTPM
  • eosinophil: 5.8 nTPM
  • naive CD4 T-cell: 5.4 nTPM
  • classical monocyte: 5.2 nTPM
  • intermediate monocyte: 5.1 nTPM
  • gdT-cell: 4.9 nTPM

Brain region

  • cerebral cortex: 17 nTPM
  • cerebellum: 16 nTPM
  • medulla oblongata: 15 nTPM
  • pons: 15 nTPM
  • thalamus: 14 nTPM
  • midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0
gnomAD missense Z
-0.25
DepMap mean gene effect
0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF561 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF561 as an antibody target. Whether an autoantibody or antibody against ZNF561 could matter depends on whether native ZNF561 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF561 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF561 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF561. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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