Seroatlas · Human Serome Atlas

ZNF560

Zinc finger protein 560

Also known as: FLJ31986, ZN560_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MR9
Gene: ZNF560
Ensembl: ENSG00000198028
Chromosome: 19
Canonical length: 790 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

790 residues, UniProt reviewed canonical sequence.

>Q96MR9|ZNF560
     1  MAYCLTNCYQ YSVTFEDTAV DFTQEEWILL DPVQRNLYRD VMLENYENVA KVGFQLFKPS
    61  VISWLEEEEL RTLQQGVLQD WAIKHQTSVS ALQQEFWKIQ TSNGIQMDLV TFDSVAVEFT
   121  QEEWTLLDPA QRNLYSDVML ENYKNLSSVG YQLFKPSLIS WLEEEEELST LPRVLQEWKM
   181  CLKTKGPALW QDNFCLKTLN GIQLARNQNG EELYDCKQCE DVFCKHPCLK TNMSTQNRGN
   241  TSECIQYAKD LLSLYNKTST IRKVSVFSKH GKSFRLILNV QVQRKCTQDK SFEGTDYGKA
   301  FIYQSYLEAH RKTQSGEKLN EWKQCGEAFT HSTSHAVNVE THIIKNPYEC KECGKDFRYP
   361  THLNNHMQTH IGIKPYKCKH CGKTFTVPSG FLEHVRTHTG EKPYGCKECG KAFGTSAGLI
   421  EHIRCHAREK TFKCDHCGKA FISYPSLFGH LRVHNGEKPY EHKEYGKAFG TSSGVIEDRR
   481  SNTGQKRFDC DQCGKVFVSF SSLFAHLRTH TGEKPFKCYK CGKPFTSSAC LRIHMRTHTE
   541  ERLYQCKKCG KAFTKCSYLT KHLRTHAGEK PYECMKCGKA FTERSYLTKH LRRHSGEKPY
   601  ECKKCGKAFT ERSDLTKHLR RHTGDKPYEY KDCGKAFVVS SSLVDHLRTH TGYKPYKCNA
   661  CEKAYSRSCV LTQHLKTHAA EKTSECNACG NSFRNSMCFH DRLKTLTKIK PYKCKDCGKA
   721  FTCHSDLTNH VRIHTGEKPY KCKECGKAFR TSSGRIQHLR THMGEKPFEC DQCGKAFASF
   781  SARIAHLKTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF560 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 5.8 nTPM

Expression across tissuesHPA

Tissue

testis: 5.8 nTPM
retina: 1.9 nTPM
placenta: 0.7 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

late primary spermatocytes: 86 nCPM
early spermatids: 62 nCPM
oocytes: 51 nCPM
early primary spermatocytes: 23 nCPM
sertoli cells: 23 nCPM
differentiating spermatogonia: 18 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
hippocampal formation: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: -0.33
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF560 as an antibody target. Whether an autoantibody or antibody against ZNF560 could matter depends on whether native ZNF560 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF560 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF560 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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