Seroatlas · Human Serome Atlas

ZNF558

Zinc finger protein 558

Also known as: FLJ30932, ZN558_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96NG5
Gene
ZNF558
Ensembl
ENSG00000167785
Chromosome
19
Canonical length
402 aa
Protein class
Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q96NG5|ZNF558
     1  MAAVILPSTA APSSLFPASQ QKGHTQGGEL VNELLTSWLR GLVTFEDVAV EFTQEEWALL
    61  DPAQRTLYRD VMLENCRNLA SLGCRVNKPS LISQLEQDKK VVTEERGILP STCPDLETLL
   121  KAKWLTPKKN VFRKEQSKGV KTERSHRGVK LNECNQCFKV FSTKSNLTQH KRIHTGEKPY
   181  DCSQCGKSFS SRSYLTIHKR IHNGEKPYEC NHCGKAFSDP SSLRLHLRIH TGEKPYECNQ
   241  CFHVFRTSCN LKSHKRIHTG ENHHECNQCG KAFSTRSSLT GHNSIHTGEK PYECHDCGKT
   301  FRKSSYLTQH VRTHTGEKPY ECNECGKSFS SSFSLTVHKR IHTGEKPYEC SDCGKAFNNL
   361  SAVKKHLRTH TGEKPYECNH CGKSFTSNSY LSVHKRIHNR WI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF558 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 15 nTPM
  • cervix: 14 nTPM
  • endometrium: 14 nTPM
  • retina: 14 nTPM
  • fallopian tube: 13 nTPM
  • thyroid gland: 12 nTPM

Single-cell type

  • gastric chief cells: 20 nCPM
  • thymic myoid cells: 16 nCPM
  • retinal horizontal cells: 16 nCPM
  • mesothelial cells: 14 nCPM
  • adrenal cortex cells: 13 nCPM
  • bergmann glia: 13 nCPM

Immune cell

  • NK-cell: 2 nTPM
  • naive CD8 T-cell: 1.5 nTPM
  • naive CD4 T-cell: 1.2 nTPM
  • memory CD8 T-cell: 1.1 nTPM
  • gdT-cell: 1 nTPM
  • naive B-cell: 1 nTPM

Brain region

  • cerebellum: 9 nTPM
  • thalamus: 8.9 nTPM
  • white matter: 8.9 nTPM
  • medulla oblongata: 8.8 nTPM
  • choroid plexus: 8.7 nTPM
  • midbrain: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
0.87
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF558 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF558 as an antibody target. Whether an autoantibody or antibody against ZNF558 could matter depends on whether native ZNF558 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF558 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF558 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF558. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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