Seroatlas · Human Serome Atlas

ZNF557

Zinc finger protein 557

Also known as: MGC4054, ZN557_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N988
Gene: ZNF557
Ensembl: ENSG00000130544
Chromosome: 19
Canonical length: 423 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Intermediate filaments

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q8N988|ZNF557
     1  MAAVVLPPTA ASQREGHTEG GELVNELLKS WLKGLVTFED VAVEFTQEEW ALLDPAQRTL
    61  YRDVMLENCR NLASLGNQVD KPRLISQLEQ EDKVMTEERG ILSGTCPDVE NPFKAKGLTP
   121  KLHVFRKEQS RNMKMERNHL GATLNECNQC FKVFSTKSSL TRHRKIHTGE RPYGCSECGK
   181  SYSSRSYLAV HKRIHNGEKP YECNDCGKTF SSRSYLTVHK RIHNGEKPYE CSDCGKTFSN
   241  SSYLRPHLRI HTGEKPYKCN QCFREFRTQS IFTRHKRVHT GEGHYVCNQC GKAFGTRSSL
   301  SSHYSIHTGE YPYECHDCGR TFRRRSNLTQ HIRTHTGEKP YTCNECGKSF TNSFSLTIHR
   361  RIHNGEKSYE CSDCGKSFNV LSSVKKHMRT HTGKKPYECN YCGKSFTSNS YLSVHTRMHN
   421  RQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF557 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 3.5 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 3.5 nTPM
lymph node: 2.3 nTPM
tonsil: 2.3 nTPM
spleen: 2.2 nTPM
thymus: 2.2 nTPM
testis: 2 nTPM

Single-cell type

early primary spermatocytes: 34 nCPM
megakaryocytes: 25 nCPM
retinal horizontal cells: 24 nCPM
differentiating spermatogonia: 22 nCPM
undifferentiated spermatogonia: 20 nCPM
myosatellite cells: 19 nCPM

Immune cell

NK-cell: 5.9 nTPM
naive CD4 T-cell: 5.8 nTPM
plasmacytoid DC: 5.7 nTPM
basophil: 5.6 nTPM
naive B-cell: 5.3 nTPM
memory CD4 T-cell: 5 nTPM

Brain region

cerebellum: 13 nTPM
white matter: 13 nTPM
cerebral cortex: 9.8 nTPM
choroid plexus: 9.7 nTPM
basal ganglia: 9.6 nTPM
pons: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.03
gnomAD missense Z: 0.61
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF557 as an antibody target. Whether an autoantibody or antibody against ZNF557 could matter depends on whether native ZNF557 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF557 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF557 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...