Seroatlas · Human Serome Atlas

ZNF556

Zinc finger protein 556

Also known as: FLJ11637, ZN556_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAH1
Gene: ZNF556
Ensembl: ENSG00000172000
Chromosome: 19
Canonical length: 456 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>Q9HAH1|ZNF556
     1  MDTVVFEDVV VDFTLEEWAL LNPAQRKLYR DVMLETFKHL ASVDNEAQLK ASGSISQQDT
    61  SGEKLSLKQK IEKFTRKNIW ASLLGKNWEE HSVKDKHNTK ERHLSRNPRV ERPCKSSKGN
   121  KRGRTFRKTR NCNRHLRKNC CTSVRRYECS QCGKLFTHSS SLIRHKRAHS GQKLYKCKEC
   181  GKAFSRPSYL QTHEKTHSGE KPYACQSCGK TFLRSHSLTE HVRTHTGEKP YECGQCGKGF
   241  SCPKSFRAHV MMHAGGRPYE CKHCGKAFRC QKSFRVHMIM HAGGRPYECK QCGKAYCWAT
   301  SFQRHVRIHN GEKPYKCGKC GKAFGWPSSL HKHARTHAKK KPVSGGSVGK SSARPRPSTD
   361  VKSQTREKVY KCETCGKTYG WSSSLHKHER KHTGEKPVNA ASVGKPSGGL CSSKNVRTQI
   421  GQKPSKCEKC GKAFSCPKAF QGHVRSHTGK KSCTSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF556 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 3.8 nTPM

Expression across tissuesHPA

Tissue

ovary: 3.8 nTPM
tongue: 3.2 nTPM
skeletal muscle: 2.3 nTPM
cerebellum: 1.9 nTPM
fallopian tube: 1.9 nTPM
esophagus: 0.6 nTPM

Single-cell type

myonuclei: 47 nCPM
pdcs: 29 nCPM
epididymal clear cells: 29 nCPM
ovarian stromal cells: 16 nCPM
myosatellite cells: 14 nCPM
breast myoepithelial cells: 9.5 nCPM

Immune cell

plasmacytoid DC: 15 nTPM
basophil: 1.4 nTPM
neutrophil: 0.8 nTPM
NK-cell: 0.4 nTPM
naive B-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM

Brain region

cerebellum: 6.7 nTPM
white matter: 4.6 nTPM
amygdala: 3.9 nTPM
cerebral cortex: 3.9 nTPM
medulla oblongata: 3.8 nTPM
basal ganglia: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: -0.78
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF556 as an antibody target. Whether an autoantibody or antibody against ZNF556 could matter depends on whether native ZNF556 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF556 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF556 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...