Seroatlas · Human Serome Atlas

ZNF552

Zinc finger protein 552

Also known as: FLJ21603, ZN552_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H707
Gene: ZNF552
Ensembl: ENSG00000178935
Chromosome: 19
Canonical length: 407 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q9H707|ZNF552
     1  MAAAALRFPV QGTVTFEDVA VKFTQEEWNL LSEAQRCLYR DVTLENLALM SSLGCWCGVE
    61  DEAAPSKQSI YIQRETQVRT PMAGVSPKKA HPCEMCGPIL GDILHVADHQ GTHHKQKLHR
   121  CEAWGNKLYD SGNFHQHQNE HIGEKPYRGS VEEALFAKRC KLHVSGESSV FSESGKDFLL
   181  RSGLLQQEAT HTGKSNSKTE CVSLFHGGKS HYSCGGCMKH FSTKDILSQH ERLLPTEEPS
   241  VWCECGKSSS KYDSFSNHQG VHTREKPYTC GICGKLFNSK SHLLVHQRIH TGEKPYECEV
   301  CQKFFRHKYH LIAHQRVHTG ERPYECSDCG KSFTHSSTFR VHKRVHTGQK PYECSECGKS
   361  FAESSSLTKH RRVHTGEKPY GCSECEKKFR QISSLRHHQR VHKRKGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF552 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

breast: 24 nTPM
salivary gland: 17 nTPM
urinary bladder: 15 nTPM
stomach: 13 nTPM
prostate: 12 nTPM
rectum: 11 nTPM

Single-cell type

prostatic hillock cells: 262 nCPM
prostatic club cells: 221 nCPM
cardiomyocytes: 126 nCPM
basal prostatic cells: 100 nCPM
syncytiotrophoblasts: 86 nCPM
papillary tip epithelial cells: 75 nCPM

Immune cell

neutrophil: 25 nTPM
eosinophil: 7.4 nTPM
naive CD4 T-cell: 4.5 nTPM
memory CD8 T-cell: 4.3 nTPM
naive CD8 T-cell: 3.8 nTPM
memory B-cell: 3.7 nTPM

Brain region

cerebellum: 48 nTPM
choroid plexus: 38 nTPM
cerebral cortex: 29 nTPM
thalamus: 26 nTPM
hippocampal formation: 26 nTPM
white matter: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: 0.98
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF552 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF552 as an antibody target. Whether an autoantibody or antibody against ZNF552 could matter depends on whether native ZNF552 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF552 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF552 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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