Seroatlas · Human Serome Atlas

ZNF551

Zinc finger protein 551

Also known as: DKFZp686H1038, ZN551_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z340
Gene: ZNF551
Ensembl: ENSG00000204519
Chromosome: 19
Canonical length: 670 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

670 residues, UniProt reviewed canonical sequence.

>Q7Z340|ZNF551
     1  MPAPVGRRSP PSPRSSMAAV ALRDSAQGMT FEDVAIYFSQ EEWELLDESQ RFLYCDVMLE
    61  NFAHVTSLGY CHGMENEAIA SEQSVSIQVR TSKGNTPTQK THLSEIKMCV PVLKDILPAA
   121  EHQTTSPVQK SYLGSTSMRG FCFSADLHQH QKHYNEEEPW KRKVDEATFV TGCRFHVLNY
   181  FTCGEAFPAP TDLLQHEATP SGEEPHSSSS KHIQAFFNAK SYYKWGEYRK ASSHKHTLVQ
   241  HQSVCSEGGL YECSKCEKAF TCKNTLVQHQ QIHTGQKMFE CSECEESFSK KCHLILHKII
   301  HTGERPYECS DREKAFIHKS EFIHHQRRHT GGVRHECGEC RKTFSYKSNL IEHQRVHTGE
   361  RPYECGECGK SFRQSSSLFR HQRVHSGERP YQCCECGKSF RQIFNLIRHR RVHTGEMPYQ
   421  CSDCGKSFSC KSELIQHQRI HSGERPYECR ECGKSFRQFS NLIRHRSIHT GDRPYECSEC
   481  EKSFSRKFIL IQHQRVHTGE RPYECSECGK SFTRKSDLIQ HRRIHTGTRP YECSECGKSF
   541  RQRSGLIQHR RLHTGERPYE CSECGKSFSQ SASLIQHQRV HTGERPYECS ECGKSFSQSS
   601  SLIQHQRGHT GERPYECSQC GKPFTHKSDL IQHQRVHTGE RPYECSECGK SFSRKSNLIR
   661  HRRVHTEERP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF551 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 8.1 nTPM
bone marrow: 7.5 nTPM
pituitary gland: 5.8 nTPM
thyroid gland: 5.8 nTPM
thymus: 4.8 nTPM
lymph node: 4.7 nTPM

Single-cell type

late primary spermatocytes: 6.5 nCPM
early spermatids: 4.5 nCPM
late spermatids: 2 nCPM
thymocytes: 1.7 nCPM
neuroendocrine cells: 0.8 nCPM
megakaryocyte progenitors: 0.7 nCPM

Immune cell

naive CD4 T-cell: 4.3 nTPM
naive CD8 T-cell: 4.1 nTPM
memory B-cell: 3.8 nTPM
MAIT T-cell: 3.3 nTPM
NK-cell: 3.1 nTPM
memory CD8 T-cell: 2.9 nTPM

Brain region

cerebellum: 19 nTPM
choroid plexus: 12 nTPM
cerebral cortex: 8.6 nTPM
hypothalamus: 8.3 nTPM
hippocampal formation: 8.2 nTPM
white matter: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0.06
gnomAD missense Z: -0.23
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF551 as an antibody target. Whether an autoantibody or antibody against ZNF551 could matter depends on whether native ZNF551 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF551 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF551 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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