ZNF547
Zinc finger protein 547
Also known as: FLJ31100, ZN547_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IVP9
- Gene
- ZNF547
- Ensembl
- ENSG00000152433
- Chromosome
- 19
- Canonical length
- 402 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
402 residues, UniProt reviewed canonical sequence.
>Q8IVP9|ZNF547
1 MAEMNPAQGH VVFEDVAIYF SQEEWGHLDE AQRLLYRDVM LENLALLSSL GCCHGAEDEE
61 APLEPGVSVG VSQVMAPKPC LSTQNTQPCE TCSSLLKDIL RLAEHDGTHP EQGLYTCPAH
121 LHQHQKEQIR EKLSRGDGGR PTFVKNHRVH MAGKTFLCSE CGKAFSHKHK LSDHQKIHTG
181 ERTYKCSKCG ILFMERSTLN RHQRTHTGER PYECNECGKA FLCKSHLVRH QTIHSGERPY
241 ECSECGKLFM WSSTLITHQR VHTGKRPYGC SECGKFFKCN SNLFRHYRIH TGKRSYGCSE
301 CGKFFMERST LSRHQRVHTG ERPYECNECG KFFSLKSVLI QHQRVHTGER PYECSECGKA
361 FLTKSHLICH QTVHTAAKQC SECGKFFRYN STLLRHQKVH TGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF547 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 7.9 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 7.9 nTPM
- retina: 4.8 nTPM
- pituitary gland: 4.5 nTPM
- spleen: 4.2 nTPM
- skin: 3.9 nTPM
- adrenal gland: 3.6 nTPM
Single-cell type
- platelets: 2.8 nCPM
- endometrial glandular cells: 0.5 nCPM
- endometrial luminal cells: 0.5 nCPM
- b-cells: 0.4 nCPM
- endometrial ciliated cells: 0.4 nCPM
- respiratory secretory cells: 0.4 nCPM
Immune cell
- memory B-cell: 4.8 nTPM
- naive B-cell: 3.2 nTPM
- NK-cell: 2.7 nTPM
- basophil: 2.6 nTPM
- intermediate monocyte: 2.5 nTPM
- MAIT T-cell: 2.5 nTPM
Brain region
- cerebellum: 16 nTPM
- hypothalamus: 8 nTPM
- cerebral cortex: 7.9 nTPM
- white matter: 7.9 nTPM
- basal ganglia: 7.8 nTPM
- midbrain: 7.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.81
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.23
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF547 as an antibody target. Whether an autoantibody or antibody against ZNF547 could matter depends on whether native ZNF547 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF547 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF547 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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