Seroatlas · Human Serome Atlas

ZNF546

Zinc finger protein 546

Also known as: MGC43537, ZN546_HUMAN, ZNF49

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UE3
Gene: ZNF546
Ensembl: ENSG00000187187
Chromosome: 19
Canonical length: 836 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

836 residues, UniProt reviewed canonical sequence.

>Q86UE3|ZNF546
     1  MQVDPPLHGP PNDFLIFQII PLHSLSIMPR FLWILCFSME ETQGELTSSC GSKTMANVSL
    61  AFRDVSIDLS QEEWECLDAV QRDLYKDVML ENYSNLVSLG YTIPKPDVIT LLEQEKEPWI
   121  VMREGTRNWF TDLEYKYITK NLLSEKNVCK IYLSQLQTGE KSKNTIHEDT IFRNGLQCKH
   181  EFERQERHQM GCVSQMLIQK QISHPLHPKI HAREKSYECK ECRKAFRQQS YLIQHLRIHT
   241  GERPYKCMEC GKAFCRVGDL RVHHTIHAGE RPYECKECGK AFRLHYHLTE HQRIHSGVKP
   301  YECKECGKAF SRVRDLRVHQ TIHAGERPYE CKECGKAFRL HYQLTEHQRI HTGERPYECK
   361  VCGKTFRVQR HISQHQKIHT GVKPYKCNEC GKAFSHGSYL VQHQKIHTGE KPYECKECGK
   421  SFSFHAELAR HRRIHTGEKP YECRECGKAF RLQTELTRHH RTHTGEKPYE CKECGKAFIC
   481  GYQLTLHLRT HTGEIPYECK ECGKTFSSRY HLTQHYRIHT GEKPYICNEC GKAFRLQGEL
   541  TRHHRIHTCE KPYECKECGK AFIHSNQFIS HQRIHTSEST YICKECGKIF SRRYNLTQHF
   601  KIHTGEKPYI CNECGKAFRF QTELTQHHRI HTGEKPYKCT ECGKAFIRST HLTQHHRIHT
   661  GEKPYECTEC GKTFSRHYHL TQHHRGHTGE KPYICNECGN AFICSYRLTL HQRIHTGELP
   721  YECKECGKTF SRRYHLTQHF RLHTGEKPYS CKECGNAFRL QAELTRHHIV HTGEKPYKCK
   781  ECGKAFSVNS ELTRHHRIHT GEKPYQCKEC GKAFIRSDQL TLHQRNHISE EVLCIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF546 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 7.3 nTPM

Expression across tissuesHPA

Tissue

testis: 7.3 nTPM
cerebellum: 2.6 nTPM
basal ganglia: 2.4 nTPM
ovary: 2.3 nTPM
pituitary gland: 2.2 nTPM
retina: 2.2 nTPM

Single-cell type

microglia: 29 nCPM
oligodendrocytes: 27 nCPM
bergmann glia: 23 nCPM
oligodendrocyte progenitor cells: 22 nCPM
ependymal cells: 21 nCPM
choroid plexus epithelial cells: 21 nCPM

Immune cell

naive CD4 T-cell: 1.3 nTPM
naive CD8 T-cell: 1.2 nTPM
gdT-cell: 1 nTPM
T-reg: 0.9 nTPM
eosinophil: 0.8 nTPM
memory B-cell: 0.8 nTPM

Brain region

white matter: 9.3 nTPM
medulla oblongata: 7.7 nTPM
cerebellum: 7.6 nTPM
basal ganglia: 7.4 nTPM
choroid plexus: 7.1 nTPM
pons: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF546 as an antibody target. Whether an autoantibody or antibody against ZNF546 could matter depends on whether native ZNF546 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF546 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF546 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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