Seroatlas · Human Serome Atlas

ZNF544

Zinc finger protein 544

Also known as: AF020591, ZN544_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NX49
Gene: ZNF544
Ensembl: ENSG00000198131
Chromosome: 19
Canonical length: 715 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

715 residues, UniProt reviewed canonical sequence.

>Q6NX49|ZNF544
     1  MEARSMLVPP QASVCFEDVA MAFTQEEWEQ LDLAQRTLYR EVTLETWEHI VSLGLFLSKS
    61  DVISQLEQEE DLCRAEQEAP RDWKATLEEN RLNSEKDRAR EELSHHVEVY RSGPEEPPSL
   121  VLGKVQDQSN QLREHQENSL RFMVLTSERL FAQREHCELE LGGGYSLPST LSLLPTTLPT
   181  STGFPKPNSQ VKELKQNSAF INHEKNGADG KHCESHQCAR AFCQSIYLSK LGNVETGKKN
   241  PYEYIVSGDS LNYGSSLCFH GRTFSVKKSD DCKDYGNLFS HSVSLNEQKP VHFGKSQYEC
   301  DECRETCSES LCLVQTERSG PGETPFRCEE RCAAFPMASS FSDCNIIQTT EKPSVCNQCG
   361  KSFSCCKLIH QRTHTGEKPF ECTQCGKSFS QSYDLVIHQR THTGEKPYEC DLCGKSFTQR
   421  SKLITHQRIH TGEKPYQCIE CRKSFRWNSN LIVHQRIHTG EKPYECTHCG KSFSQSYELV
   481  THKRTHTGEK PFKCTQCGKS FSQKYDLVVH QRTHTGEKPY ECNLCGKSFS QSSKLITHQR
   541  IHTGEKPYQC IECGKSFRWN SNLVIHQRIH TGEKPYDCTH CGKSFSQSYQ LVAHKRTHTG
   601  EKPYECNECG KAFNRSTQLI RHLQIHTGEK PYKCNQCNKA FARSSYLVMH QRTHTGEKPF
   661  ECSQCGKAFS GSSNLLSHHR IHSGEKPYEC SDCGKSFRQQ SQLVVHRRTH TGEKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF544 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

epididymis: 36 nTPM
parathyroid gland: 24 nTPM
fallopian tube: 23 nTPM
testis: 22 nTPM
retina: 21 nTPM
thyroid gland: 19 nTPM

Single-cell type

late spermatids: 52 nCPM
late primary spermatocytes: 38 nCPM
early primary spermatocytes: 26 nCPM
early spermatids: 26 nCPM
megakaryocytes: 19 nCPM
differentiating spermatogonia: 12 nCPM

Immune cell

NK-cell: 17 nTPM
eosinophil: 15 nTPM
naive B-cell: 14 nTPM
naive CD8 T-cell: 12 nTPM
memory B-cell: 11 nTPM
memory CD8 T-cell: 9.5 nTPM

Brain region

cerebellum: 62 nTPM
choroid plexus: 62 nTPM
hippocampal formation: 42 nTPM
midbrain: 41 nTPM
medulla oblongata: 40 nTPM
cerebral cortex: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: -0.72
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF544 as an antibody target. Whether an autoantibody or antibody against ZNF544 could matter depends on whether native ZNF544 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF544 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF544 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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