Seroatlas · Human Serome Atlas

ZNF536

Zinc finger protein 536

Also known as: KIAA0390, ZN536_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15090
Gene: ZNF536
Ensembl: ENSG00000198597
Chromosome: 19
Canonical length: 1300 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

The protein encoded by this gene is a highly conserved zinc finger protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

1300 residues, UniProt reviewed canonical sequence.

>O15090|ZNF536
     1  MEEASLCLGV SSAEPEAEPH LSGPVLNGQY AMSQKLHQIT SQLSHAFPEL HPRPNPEEKP
    61  PASLEEKAHV PMSGQPMGSQ MALLANQLGR EVDTSLNGRV DLQQFLNGQN LGIMSQMSDI
   121  EDDARKNRKY PCPLCGKRFR FNSILSLHMR THTGEKPFKC PYCDHRAAQK GNLKIHLRTH
   181  KLGNLGKGRG RVREENRLLH ELEERAILRD KQLKGSLLQP RPDLKPPPHA QQAPLAACTL
   241  ALQANHSVPD VAHPVPSPKP ASVQEDAVAP AAGFRCTFCK GKFKKREELD RHIRILHKPY
   301  KCTLCDFAAS QEEELISHVE KAHITAESAQ GQGPNGGGEQ SANEFRCEVC GQVFSQAWFL
   361  KGHMRKHKDS FEHCCQICGR RFKEPWFLKN HMKVHLNKLS VKNKSPSDPE VPVPMGGMSQ
   421  EAHANLYSRY LSCLQSGFMT PDKAGLSEPS QLYGKGELPM KEKEALGKLL SPISSMAHGV
   481  PEGDKHSLLG CLNLVPPLKS SCIERLQAAA KAAEMDPVNS YQAWQLMARG MAMEHGFLSK
   541  EHPLQRNHED TLANAGVLFD KEKREYVLVG ADGSKQKMPA DLVHSTKVGS QRDLPSKLDP
   601  LESSRDFLSH GLNQTLEYNL QGPGNMKEKP TECPDCGRVF RTYHQVVVHS RVHKRDRKGE
   661  EDGLHVGLDE RRGSGSDQES QSVSRSTTPG SSNVTEESGV GGGLSQTGSA QEDSPHPSSP
   721  SSSDIGEEAG RSAGVQQPAL LRDRSLGSAM KDCPYCGKTF RTSHHLKVHL RIHTGEKPYK
   781  CPHCDYAGTQ SASLKYHLER HHRERQNGAG PLSGQPPNQD HKDEMSSKAS LFIRPDILRG
   841  AFKGLPGIDF RGGPASQQWT SGVLSSGDHS GQATGMSSEV PSDALKGTDL PSKSTHFSEI
   901  GRAYQSIVSN GVNFQGSLQA FMDSFVLSSL KKEKDMKDKA LADPPSMKVH GVDGGEEKPS
   961  GKSSQRKSEK SQYEPLDLSV RPDAASLPGS SVTVQDSIAW HGCLFCAFTT SSMELMALHL
  1021  QANHLGKAKR KDNTIGVTVN CKDQAREASK MALLPSLQSN KDLGLSNMIS SLDSASEKMA
  1081  QGQLKETLGE QKSGAWTGHV DPAFCNFPSD FYKQFGVYPG MVGSGASSSC PNKEPDGKAH
  1141  SEEDVPILIP ETTSKNTTDD LSDIASSEDM DSSKGENNDE EDVETEPEMM TKPLSALSKD
  1201  SSSDGGDSLQ PTGTSQPVQG LVSPLSQAPE KQWHSQGLLQ AQDPLAGLPK PERGPQSLDK
  1261  PMNMLSVLRA YSSDGLAAFN GLASSTANSG CIKRPDLCGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF536 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 30 nTPM
midbrain: 17 nTPM
cerebellum: 16 nTPM
hippocampal formation: 16 nTPM
amygdala: 11 nTPM
basal ganglia: 11 nTPM

Single-cell type

oligodendrocytes: 1,123 nCPM
choroid plexus epithelial cells: 995 nCPM
retinal pigment epithelial cells: 755 nCPM
müller glia: 527 nCPM
somatotrophs: 500 nCPM
schwann cells: 466 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 141 nTPM
basal ganglia: 81 nTPM
cerebral cortex: 81 nTPM
thalamus: 72 nTPM
medulla oblongata: 72 nTPM
pons: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 2.4
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Zinc finger C2H2-type
Zinc finger C2H2 superfamily
Krueppel C2H2-type Zinc-Finger Domain-Containing Protein
Zinc finger, C2H2 type
C2H2-type zinc-finger domain
Unstructured conserved, between two C2H2-type zinc-fingers

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF536 as an antibody target. Whether an autoantibody or antibody against ZNF536 could matter depends on whether native ZNF536 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF536 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF536 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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