Seroatlas · Human Serome Atlas

ZNF534

Zinc finger protein 534

Also known as: FLJ25344, KRBO3, ZN534_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q76KX8
Gene
ZNF534
Ensembl
ENSG00000198633
Chromosome
19
Canonical length
674 aa
Protein class
Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

674 residues, UniProt reviewed canonical sequence.

>Q76KX8|ZNF534
     1  MALTQGQLSF SDVAIEFSQE EWKCLDPGQK ALYRDVMLEN YRNLVSLGED NVRPEACICS
    61  GICLPDLSVT SMLEQKRDPW TLQSEVKIIN NPDGRECIKG VNTEKSSKLG SSAGNKSLKN
   121  QHGLTLQLHL TEWQPFQAVR NIYGCKHVEK SISDNSSVSP VQISFFSVKT HIFNNYRNDF
   181  LFSTLLPQEQ KVHIREKPYG CNEHGKVFRV SSSLTNRQVI HIADKTYKCS DCGEIFSSNS
   241  NFAQHQRIHT GEKPYKYNEC GKVFNQNSHL AQHQKIHTGQ KPYNNKECGK VFSHHAYLAQ
   301  HRKIHTGEKP YKCSECGKAF SVCSSLTAHL VIHTGEKPYD CKECGKVFRH KSSLTTHQTV
   361  HTGERPYKCN ECGKGFSRIA FLARHRKVHT GEKPYKCNEC GKVFIGNSRL ARHRKIHTGG
   421  RRYKCNECGK AFRTCSDLTA HLLIHTGEKP YECIDCGKVF RHKSSLTYHC RIHTGEKPYK
   481  CNECGKVFSQ NSNLQRHRKI HTGEKLYKCN ECGKVFRQNS HLAQHRDIHT GEKPYSCNEC
   541  GKVFRRNSHL VRHRNVHTGE KPYSCNECGK VFSRNSHLAR HRNIHTGEKP HSCNECGKVF
   601  SRNSHLARHR KIHTGEKLYK CNECSKVFSR NSRLAQHRNI HTGVKPYSCN ECGKVFSKNS
   661  ILVQHCSIHT REKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF534 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
2.4 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 2.4 nTPM
  • cerebellum: 2.2 nTPM
  • testis: 1.8 nTPM
  • amygdala: 1.1 nTPM
  • cerebral cortex: 1.1 nTPM
  • hippocampal formation: 1.1 nTPM

Single-cell type

  • differentiating spermatogonia: 22 nCPM
  • oocytes: 18 nCPM
  • early primary spermatocytes: 13 nCPM
  • retinal amacrine cells: 12 nCPM
  • undifferentiated spermatogonia: 12 nCPM
  • brain inhibitory neurons: 11 nCPM

Immune cell

  • basophil: 0.5 nTPM
  • neutrophil: 0.5 nTPM
  • classical monocyte: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • basal ganglia: 6.7 nTPM
  • cerebellum: 6.5 nTPM
  • cerebral cortex: 6.5 nTPM
  • hippocampal formation: 6.4 nTPM
  • amygdala: 5.7 nTPM
  • white matter: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.89
gnomAD pLI
0
gnomAD missense Z
0.35
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF534 as an antibody target. Whether an autoantibody or antibody against ZNF534 could matter depends on whether native ZNF534 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF534 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF534 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF534. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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