Seroatlas · Human Serome Atlas

ZNF532

Zinc finger protein 532

Also known as: FLJ10697, ZN532_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCE3
Gene: ZNF532
Ensembl: ENSG00000074657
Chromosome: 18
Canonical length: 1301 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1301 residues, UniProt reviewed canonical sequence.

>Q9HCE3|ZNF532
     1  MTMGDMKTPD FDDLLAAFDI PDMVDPKAAI ESGHDDHESH MKQNAHGEDD SHAPSSSDVG
    61  VSVIVKNVRN IDSSEGGEKD GHNPTGNGLH NGFLTASSLD SYSKDGAKSL KGDVPASEVT
   121  LKDSTFSQFS PISSAEEFDD DEKIEVDDPP DKEDMRSSFR SNVLTGSAPQ QDYDKLKALG
   181  GENSSKTGLS TSGNVEKNKA VKRETEASSI NLSVYEPFKV RKAEDKLKES SDKVLENRVL
   241  DGKLSSEKND TSLPSVAPSK TKSSSKLSSC IAAIAALSAK KAASDSCKEP VANSRESSPL
   301  PKEVNDSPRA ADKSPESQNL IDGTKKPSLK QPDSPRSISS ENSSKGSPSS PAGSTPAIPK
   361  VRIKTIKTSS GEIKRTVTRV LPEVDLDSGK KPSEQTASVM ASVTSLLSSP ASAAVLSSPP
   421  RAPLQSAVVT NAVSPAELTP KQVTIKPVAT AFLPVSAVKT AGSQVINLKL ANNTTVKATV
   481  ISAASVQSAS SAIIKAANAI QQQTVVVPAS SLANAKLVPK TVHLANLNLL PQGAQATSEL
   541  RQVLTKPQQQ IKQAIINAAA SQPPKKVSRV QVVSSLQSSV VEAFNKVLSS VNPVPVYIPN
   601  LSPPANAGIT LPTRGYKCLE CGDSFALEKS LTQHYDRRSV RIEVTCNHCT KNLVFYNKCS
   661  LLSHARGHKE KGVVMQCSHL ILKPVPADQM IVSPSSNTST STSTLQSPVG AGTHTVTKIQ
   721  SGITGTVISA PSSTPITPAM PLDEDPSKLC RHSLKCLECN EVFQDETSLA THFQQAADTS
   781  GQKTCTICQM LLPNQCSYAS HQRIHQHKSP YTCPECGAIC RSVHFQTHVT KNCLHYTRRV
   841  GFRCVHCNVV YSDVAALKSH IQGSHCEVFY KCPICPMAFK SAPSTHSHAY TQHPGIKIGE
   901  PKIIYKCSMC DTVFTLQTLL YRHFDQHIEN QKVSVFKCPD CSLLYAQKQL MMDHIKSMHG
   961  TLKSIEGPPN LGINLPLSIK PATQNSANQN KEDTKSMNGK EKLEKKSPSP VKKSMETKKV
  1021  ASPGWTCWEC DCLFMQRDVY ISHVRKEHGK QMKKHPCRQC DKSFSSSHSL CRHNRIKHKG
  1081  IRKVYACSHC PDSRRTFTKR LMLEKHVQLM HGIKDPDLKE MTDATNEEET EIKEDTKVPS
  1141  PKRKLEEPVL EFRPPRGAIT QPLKKLKINV FKVHKCAVCG FTTENLLQFH EHIPQHKSDG
  1201  SSYQCRECGL CYTSHVSLSR HLFIVHKLKE PQPVSKQNGA GEDNQQENKP SHEDESPDGA
  1261  VSDRKCKVCA KTFETEAALN THMRTHGMAF IKSKRMSSAE K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF532 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 62 nTPM
endometrium: 61 nTPM
skeletal muscle: 57 nTPM
ovary: 48 nTPM
blood vessel: 47 nTPM
tongue: 47 nTPM

Single-cell type

prostatic glandular cells: 1,098 nCPM
bergmann glia: 381 nCPM
pituitary stem cells: 377 nCPM
myonuclei: 299 nCPM
oligodendrocytes: 221 nCPM
lactotrophs: 200 nCPM

Immune cell

memory B-cell: 3.8 nTPM
naive B-cell: 1.6 nTPM
intermediate monocyte: 1.1 nTPM
myeloid DC: 0.7 nTPM
gdT-cell: 0.4 nTPM
total PBMC: 0.4 nTPM

Brain region

white matter: 231 nTPM
cerebellum: 216 nTPM
medulla oblongata: 185 nTPM
basal ganglia: 172 nTPM
pons: 171 nTPM
thalamus: 159 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.99
gnomAD missense Z: 2.68
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF532 as an antibody target. Whether an autoantibody or antibody against ZNF532 could matter depends on whether native ZNF532 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF532 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF532 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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